Estradiol-tethered micropatterned surfaces for the study of estrogenic non-genomic pathways

B. Qi, Y. Shimizu, J. Nakanishi*, F. M. Winnik

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Besides its well-known hormonal effects initiated in the nucleus, estradiol (E2) also activates non-nuclear pathways through interactions with receptors located on the cell plasma membrane. Micropatterned substrates consisting of gold dots bearing tethered E2 distributed on a cell-adhesive substrate were prepared and shown to trigger specifically E2 non-genomic effects in cells grown on the substrates.

Original languageEnglish
Pages (from-to)10056-10059
Number of pages4
JournalChemical Communications
Volume52
Issue number65
DOIs
Publication statusPublished - 2016
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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