Estrogen modulates central and peripheral responses to cold in female rats

Yuki Uchida, Masumi Kano, Saki Yasuhara, Akiko Kobayashi, Ken Tokizawa, Kei Nagashima

    Research output: Contribution to journalArticle

    13 Citations (Scopus)

    Abstract

    The aim of this study was to determine whether estrogen modulates central and peripheral responses to cold in female rats. In ovariectomized female rats with and without administered estrogen [E2 (+) and E2 (-), respectively], the counts of cFos-immunoreactive cells in the medial preoptic nucleus (MPO) and dorsomedial hypothalamic nucleus (DMH) in the hypothalamus were greater in the E2 (+) rats than in the E2 (-) rats at 5°C. Examination of the response of normal female rats to exposure to 5°C at different phases of the estrus cycle revealed that counts of cFos-immunoreactive cells in the MPO, DMH, and posterior hypothalamus and the level of uncoupling protein 1 mRNA in the brown adipose tissues were greater in the proestrus phase than on day 1 of the diestrus phase. This result was linked to the level of plasma estrogen. The body temperature during cold exposure was higher in the E2 (+) rats than in the E2 (-) rats and was also higher in the proestrus phase than on day 1 of the diestrus phase. We conclude that estrogen may affect central and peripheral responses involved in thermoregulation in the cold.

    Original languageEnglish
    Pages (from-to)151-160
    Number of pages10
    JournalJournal of Physiological Sciences
    Volume60
    Issue number2
    DOIs
    Publication statusPublished - 2010 Mar

    Fingerprint

    Estrogens
    Dorsomedial Hypothalamic Nucleus
    Diestrus
    Proestrus
    Preoptic Area
    Posterior Hypothalamus
    Brown Adipose Tissue
    Body Temperature Regulation
    Estrus
    Body Temperature
    Hypothalamus
    Messenger RNA

    Keywords

    • CFos
    • Hypothalamus
    • Sex hormones
    • Thermoregulation
    • Uncoupling protein 1

    ASJC Scopus subject areas

    • Physiology

    Cite this

    Estrogen modulates central and peripheral responses to cold in female rats. / Uchida, Yuki; Kano, Masumi; Yasuhara, Saki; Kobayashi, Akiko; Tokizawa, Ken; Nagashima, Kei.

    In: Journal of Physiological Sciences, Vol. 60, No. 2, 03.2010, p. 151-160.

    Research output: Contribution to journalArticle

    Uchida, Yuki ; Kano, Masumi ; Yasuhara, Saki ; Kobayashi, Akiko ; Tokizawa, Ken ; Nagashima, Kei. / Estrogen modulates central and peripheral responses to cold in female rats. In: Journal of Physiological Sciences. 2010 ; Vol. 60, No. 2. pp. 151-160.
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