Estrogen modulates central and peripheral responses to cold in female rats

Yuki Uchida, Masumi Kano, Saki Yasuhara, Akiko Kobayashi, Ken Tokizawa, Kei Nagashima

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The aim of this study was to determine whether estrogen modulates central and peripheral responses to cold in female rats. In ovariectomized female rats with and without administered estrogen [E2 (+) and E2 (-), respectively], the counts of cFos-immunoreactive cells in the medial preoptic nucleus (MPO) and dorsomedial hypothalamic nucleus (DMH) in the hypothalamus were greater in the E2 (+) rats than in the E2 (-) rats at 5°C. Examination of the response of normal female rats to exposure to 5°C at different phases of the estrus cycle revealed that counts of cFos-immunoreactive cells in the MPO, DMH, and posterior hypothalamus and the level of uncoupling protein 1 mRNA in the brown adipose tissues were greater in the proestrus phase than on day 1 of the diestrus phase. This result was linked to the level of plasma estrogen. The body temperature during cold exposure was higher in the E2 (+) rats than in the E2 (-) rats and was also higher in the proestrus phase than on day 1 of the diestrus phase. We conclude that estrogen may affect central and peripheral responses involved in thermoregulation in the cold.

Original languageEnglish
Pages (from-to)151-160
Number of pages10
JournalJournal of Physiological Sciences
Volume60
Issue number2
DOIs
Publication statusPublished - 2010 Mar 1

Keywords

  • CFos
  • Hypothalamus
  • Sex hormones
  • Thermoregulation
  • Uncoupling protein 1

ASJC Scopus subject areas

  • Physiology

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