EVAHEART™

An Implantable Centrifugal Blood Pump for Long-Term Circulatory Support

Kenji Yamazaki, Shinichiro Kihara, Takehide Akimoto, Osamu Tagusari, Akihiko Kawai, Mitsuo Umezu, Jun Tomioka, Robert L. Kormos, Bartley P. Griffith, Hiromi Kurosawa

    Research output: Contribution to journalArticle

    64 Citations (Scopus)

    Abstract

    Objective: We developed "EVAHEART™": a compact centrifugal blood pump system as an implantable left ventricular assist device for long-term circulatory support. The 55 × 64 mm pump is made from pure titanium, and weighs 370 g. The entire blood-contacting surface is covered with an anti-thrombogenic coating of diamond like carbon (DLC) or 2-methacryloyloxyethyl phosphorylcholine (MPC) to improve blood compatibility. Flows exceeding 12 L/min against 100 mmHg pressure at 2600 rpm was measured. A low-temperature mechanical seal with recirculating cooling system is used to seal the shaft. EVAHEART™ demonstrated an acceptably low hemolysis rate with normalized index of hemolysis of 0.005 ± 0.002 g/100L. Methods: We evaluated the pump in long-term in-vivo experiments with seven calves. Via left thoracotomy, we conducted left ventricular apex-descending aorta bypass, placing the pump in the left thoracic cavity. Results: Pump flow rates was maintained at 5-9 L/min, pump power consumption remained stable at 9-10 W in all cases, plasma free Hb levels were less than 15 mg/dl, and the seal system showed good seal capability throughout the experiments. The calves were sacrificed on schedule on postoperative day 200, 222, 142, 90, 151, 155, and 133. No thrombi formed on the blood contacting surface with either the DLC or MPC coating, and no major organ thromboembolisms occurred except for a few small renal infarcts. Conclusion: EVAHEART™ centrifugal blood pump demonstrated excellent performance in long-term in-vivo experiments.

    Original languageEnglish
    Pages (from-to)461-465
    Number of pages5
    JournalJapanese Journal of Thoracic and Cardiovascular Surgery
    Volume50
    Issue number11
    Publication statusPublished - 2002 Nov

    Fingerprint

    Diamond
    Hemolysis
    Carbon
    Thoracic Cavity
    Heart-Assist Devices
    Thromboembolism
    Thoracotomy
    Titanium
    Thoracic Aorta
    Appointments and Schedules
    Thrombosis
    Kidney
    Pressure
    Temperature
    2-methacryloyloxyethyl phosphorylcholine

    Keywords

    • Artificial heart
    • Centrifugal blood pump
    • EVAHEART
    • Left ventricular assist device

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine

    Cite this

    Yamazaki, K., Kihara, S., Akimoto, T., Tagusari, O., Kawai, A., Umezu, M., ... Kurosawa, H. (2002). EVAHEART™: An Implantable Centrifugal Blood Pump for Long-Term Circulatory Support. Japanese Journal of Thoracic and Cardiovascular Surgery, 50(11), 461-465.

    EVAHEART™ : An Implantable Centrifugal Blood Pump for Long-Term Circulatory Support. / Yamazaki, Kenji; Kihara, Shinichiro; Akimoto, Takehide; Tagusari, Osamu; Kawai, Akihiko; Umezu, Mitsuo; Tomioka, Jun; Kormos, Robert L.; Griffith, Bartley P.; Kurosawa, Hiromi.

    In: Japanese Journal of Thoracic and Cardiovascular Surgery, Vol. 50, No. 11, 11.2002, p. 461-465.

    Research output: Contribution to journalArticle

    Yamazaki, K, Kihara, S, Akimoto, T, Tagusari, O, Kawai, A, Umezu, M, Tomioka, J, Kormos, RL, Griffith, BP & Kurosawa, H 2002, 'EVAHEART™: An Implantable Centrifugal Blood Pump for Long-Term Circulatory Support', Japanese Journal of Thoracic and Cardiovascular Surgery, vol. 50, no. 11, pp. 461-465.
    Yamazaki, Kenji ; Kihara, Shinichiro ; Akimoto, Takehide ; Tagusari, Osamu ; Kawai, Akihiko ; Umezu, Mitsuo ; Tomioka, Jun ; Kormos, Robert L. ; Griffith, Bartley P. ; Kurosawa, Hiromi. / EVAHEART™ : An Implantable Centrifugal Blood Pump for Long-Term Circulatory Support. In: Japanese Journal of Thoracic and Cardiovascular Surgery. 2002 ; Vol. 50, No. 11. pp. 461-465.
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    AU - Yamazaki, Kenji

    AU - Kihara, Shinichiro

    AU - Akimoto, Takehide

    AU - Tagusari, Osamu

    AU - Kawai, Akihiko

    AU - Umezu, Mitsuo

    AU - Tomioka, Jun

    AU - Kormos, Robert L.

    AU - Griffith, Bartley P.

    AU - Kurosawa, Hiromi

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    N2 - Objective: We developed "EVAHEART™": a compact centrifugal blood pump system as an implantable left ventricular assist device for long-term circulatory support. The 55 × 64 mm pump is made from pure titanium, and weighs 370 g. The entire blood-contacting surface is covered with an anti-thrombogenic coating of diamond like carbon (DLC) or 2-methacryloyloxyethyl phosphorylcholine (MPC) to improve blood compatibility. Flows exceeding 12 L/min against 100 mmHg pressure at 2600 rpm was measured. A low-temperature mechanical seal with recirculating cooling system is used to seal the shaft. EVAHEART™ demonstrated an acceptably low hemolysis rate with normalized index of hemolysis of 0.005 ± 0.002 g/100L. Methods: We evaluated the pump in long-term in-vivo experiments with seven calves. Via left thoracotomy, we conducted left ventricular apex-descending aorta bypass, placing the pump in the left thoracic cavity. Results: Pump flow rates was maintained at 5-9 L/min, pump power consumption remained stable at 9-10 W in all cases, plasma free Hb levels were less than 15 mg/dl, and the seal system showed good seal capability throughout the experiments. The calves were sacrificed on schedule on postoperative day 200, 222, 142, 90, 151, 155, and 133. No thrombi formed on the blood contacting surface with either the DLC or MPC coating, and no major organ thromboembolisms occurred except for a few small renal infarcts. Conclusion: EVAHEART™ centrifugal blood pump demonstrated excellent performance in long-term in-vivo experiments.

    AB - Objective: We developed "EVAHEART™": a compact centrifugal blood pump system as an implantable left ventricular assist device for long-term circulatory support. The 55 × 64 mm pump is made from pure titanium, and weighs 370 g. The entire blood-contacting surface is covered with an anti-thrombogenic coating of diamond like carbon (DLC) or 2-methacryloyloxyethyl phosphorylcholine (MPC) to improve blood compatibility. Flows exceeding 12 L/min against 100 mmHg pressure at 2600 rpm was measured. A low-temperature mechanical seal with recirculating cooling system is used to seal the shaft. EVAHEART™ demonstrated an acceptably low hemolysis rate with normalized index of hemolysis of 0.005 ± 0.002 g/100L. Methods: We evaluated the pump in long-term in-vivo experiments with seven calves. Via left thoracotomy, we conducted left ventricular apex-descending aorta bypass, placing the pump in the left thoracic cavity. Results: Pump flow rates was maintained at 5-9 L/min, pump power consumption remained stable at 9-10 W in all cases, plasma free Hb levels were less than 15 mg/dl, and the seal system showed good seal capability throughout the experiments. The calves were sacrificed on schedule on postoperative day 200, 222, 142, 90, 151, 155, and 133. No thrombi formed on the blood contacting surface with either the DLC or MPC coating, and no major organ thromboembolisms occurred except for a few small renal infarcts. Conclusion: EVAHEART™ centrifugal blood pump demonstrated excellent performance in long-term in-vivo experiments.

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    KW - Left ventricular assist device

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