Evaluation of a new solution containing trehalose for twenty-hour canine lung preservation

Naohiro Kajiwara, Masahiko Taguchi, Hiroshi Saito, Shin Nakajima, Aeru Hayashi, Norihiko Kawate, Chimori Konaka, Hiromi Wada, Harubumi Kato

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

We examined the efficacy of two new preservation solutions containing trehalose - an extracellular type (ET-K) of solution and an intracellular type (IT-K) of solution - in relation to that of Euro-Collins (EC) solution in 20-h canine lung preservation. Canine lungs were flushed with one of the three solutions (n = 5 for each solution) after pretreatment with PGE1 (20 μg/kg) and were stored for 20 h at 4°C. The left lungs were transplanted and evaluated to 6 h post transplant. In the ET-K group, the arterial oxygen tension after reperfusion was significantly higher than in the IT-K and EC groups. The pulmonary vascular resistance, wet/dry weight ratio, and histological evaluation of each transplanted lung in the ET-K group were also better than in the IT-K and EC groups. This indicates that ET-K solution is useful for 20-h preservation of canine lung grafts.

Original languageEnglish
Pages (from-to)194-200
Number of pages7
JournalTransplant International
Volume9
Issue number3
DOIs
Publication statusPublished - 1996 May 1
Externally publishedYes

Keywords

  • Lung preservation, dog, trehalose
  • Preservation, lung, trehalose
  • Trehalose, lung preservation

ASJC Scopus subject areas

  • Transplantation

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