Abstract
Evaluation of antiangiogenic activity of marine sponge derived azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells was carried out. Azumamide E (5) strongly inhibited in vitro angiogenesis from iPS cells at 1.9 μM while azumamide A (1) showed only weak inhibition at 19 μM. These results were well correlated with HDAC inhibitory activity of these compounds, revealing the prospect of azumamides as the probe molecules useful for stem cell chemical biology.
| Original language | English |
|---|---|
| Pages (from-to) | 2982-2984 |
| Number of pages | 3 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 18 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2008 May 1 |
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Keywords
- Angiogenesis
- Chemical biology
- Histone deacetylase
- iPS cells
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Organic Chemistry
- Drug Discovery
- Pharmaceutical Science
Cite this
Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells. / Nakao, Youichi; Narazaki, Genta; Hoshino, Takuhiro; Maeda, Satoko; Yoshida, Minoru; Maejima, Hiroshi; Yamashita, Jun K.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 18, No. 9, 01.05.2008, p. 2982-2984.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells
AU - Nakao, Youichi
AU - Narazaki, Genta
AU - Hoshino, Takuhiro
AU - Maeda, Satoko
AU - Yoshida, Minoru
AU - Maejima, Hiroshi
AU - Yamashita, Jun K.
PY - 2008/5/1
Y1 - 2008/5/1
N2 - Evaluation of antiangiogenic activity of marine sponge derived azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells was carried out. Azumamide E (5) strongly inhibited in vitro angiogenesis from iPS cells at 1.9 μM while azumamide A (1) showed only weak inhibition at 19 μM. These results were well correlated with HDAC inhibitory activity of these compounds, revealing the prospect of azumamides as the probe molecules useful for stem cell chemical biology.
AB - Evaluation of antiangiogenic activity of marine sponge derived azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells was carried out. Azumamide E (5) strongly inhibited in vitro angiogenesis from iPS cells at 1.9 μM while azumamide A (1) showed only weak inhibition at 19 μM. These results were well correlated with HDAC inhibitory activity of these compounds, revealing the prospect of azumamides as the probe molecules useful for stem cell chemical biology.
KW - Angiogenesis
KW - Chemical biology
KW - Histone deacetylase
KW - iPS cells
UR - http://www.scopus.com/inward/record.url?scp=42949139951&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=42949139951&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2008.03.053
DO - 10.1016/j.bmcl.2008.03.053
M3 - Article
C2 - 18397826
AN - SCOPUS:42949139951
VL - 18
SP - 2982
EP - 2984
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 9
ER -