Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells

Yoichi Nakao, Genta Narazaki, Takuhiro Hoshino, Satoko Maeda, Minoru Yoshida, Hiroshi Maejima, Jun K. Yamashita

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Evaluation of antiangiogenic activity of marine sponge derived azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells was carried out. Azumamide E (5) strongly inhibited in vitro angiogenesis from iPS cells at 1.9 μM while azumamide A (1) showed only weak inhibition at 19 μM. These results were well correlated with HDAC inhibitory activity of these compounds, revealing the prospect of azumamides as the probe molecules useful for stem cell chemical biology.

Original languageEnglish
Pages (from-to)2982-2984
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume18
Issue number9
DOIs
Publication statusPublished - 2008 May 1

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Keywords

  • Angiogenesis
  • Chemical biology
  • Histone deacetylase
  • iPS cells

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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