Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells

Yoichi Nakao; Genta Narazaki; Takuhiro Hoshino; Satoko Maeda; Minoru Yoshida; Hiroshi Maejima; Jun K. Yamashita

doi:10.1016/j.bmcl.2008.03.053

Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells

Yoichi Nakao, Genta Narazaki, Takuhiro Hoshino, Satoko Maeda, Minoru Yoshida, Hiroshi Maejima, Jun K. Yamashita

School of Advanced Science and Engineering

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Evaluation of antiangiogenic activity of marine sponge derived azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells was carried out. Azumamide E (5) strongly inhibited in vitro angiogenesis from iPS cells at 1.9 μM while azumamide A (1) showed only weak inhibition at 19 μM. These results were well correlated with HDAC inhibitory activity of these compounds, revealing the prospect of azumamides as the probe molecules useful for stem cell chemical biology.

Original language	English
Pages (from-to)	2982-2984
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	18
Issue number	9
DOIs	https://doi.org/10.1016/j.bmcl.2008.03.053
Publication status	Published - 2008 May 1

Keywords

Angiogenesis
Chemical biology
Histone deacetylase
iPS cells

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells. / Nakao, Yoichi; Narazaki, Genta; Hoshino, Takuhiro; Maeda, Satoko; Yoshida, Minoru; Maejima, Hiroshi; Yamashita, Jun K.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 18, No. 9, 01.05.2008, p. 2982-2984.

Research output: Contribution to journal › Article › peer-review

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title = "Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells",

abstract = "Evaluation of antiangiogenic activity of marine sponge derived azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells was carried out. Azumamide E (5) strongly inhibited in vitro angiogenesis from iPS cells at 1.9 μM while azumamide A (1) showed only weak inhibition at 19 μM. These results were well correlated with HDAC inhibitory activity of these compounds, revealing the prospect of azumamides as the probe molecules useful for stem cell chemical biology.",

keywords = "Angiogenesis, Chemical biology, Histone deacetylase, iPS cells",

author = "Yoichi Nakao and Genta Narazaki and Takuhiro Hoshino and Satoko Maeda and Minoru Yoshida and Hiroshi Maejima and Yamashita, {Jun K.}",

note = "Funding Information: This work was partly supported by the Waseda University Grant for Special Research Projects, the Nissui Research foundation, and a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan. ",

year = "2008",

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AU - Nakao, Yoichi

AU - Narazaki, Genta

AU - Hoshino, Takuhiro

AU - Maeda, Satoko

AU - Yoshida, Minoru

AU - Maejima, Hiroshi

AU - Yamashita, Jun K.

N1 - Funding Information: This work was partly supported by the Waseda University Grant for Special Research Projects, the Nissui Research foundation, and a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan.

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N2 - Evaluation of antiangiogenic activity of marine sponge derived azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells was carried out. Azumamide E (5) strongly inhibited in vitro angiogenesis from iPS cells at 1.9 μM while azumamide A (1) showed only weak inhibition at 19 μM. These results were well correlated with HDAC inhibitory activity of these compounds, revealing the prospect of azumamides as the probe molecules useful for stem cell chemical biology.

AB - Evaluation of antiangiogenic activity of marine sponge derived azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells was carried out. Azumamide E (5) strongly inhibited in vitro angiogenesis from iPS cells at 1.9 μM while azumamide A (1) showed only weak inhibition at 19 μM. These results were well correlated with HDAC inhibitory activity of these compounds, revealing the prospect of azumamides as the probe molecules useful for stem cell chemical biology.

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KW - Chemical biology

KW - Histone deacetylase

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Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells

Abstract

Keywords

ASJC Scopus subject areas

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