Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells

Youichi Nakao, Genta Narazaki, Takuhiro Hoshino, Satoko Maeda, Minoru Yoshida, Hiroshi Maejima, Jun K. Yamashita

    Research output: Contribution to journalArticle

    24 Citations (Scopus)

    Abstract

    Evaluation of antiangiogenic activity of marine sponge derived azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells was carried out. Azumamide E (5) strongly inhibited in vitro angiogenesis from iPS cells at 1.9 μM while azumamide A (1) showed only weak inhibition at 19 μM. These results were well correlated with HDAC inhibitory activity of these compounds, revealing the prospect of azumamides as the probe molecules useful for stem cell chemical biology.

    Original languageEnglish
    Pages (from-to)2982-2984
    Number of pages3
    JournalBioorganic and Medicinal Chemistry Letters
    Volume18
    Issue number9
    DOIs
    Publication statusPublished - 2008 May 1

    Fingerprint

    Induced Pluripotent Stem Cells
    Stem cells
    Blood Vessels
    Porifera
    Cell Biology
    Stem Cells
    Molecules
    In Vitro Techniques
    azumamide E

    Keywords

    • Angiogenesis
    • Chemical biology
    • Histone deacetylase
    • iPS cells

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Biology
    • Organic Chemistry
    • Drug Discovery
    • Pharmaceutical Science

    Cite this

    Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells. / Nakao, Youichi; Narazaki, Genta; Hoshino, Takuhiro; Maeda, Satoko; Yoshida, Minoru; Maejima, Hiroshi; Yamashita, Jun K.

    In: Bioorganic and Medicinal Chemistry Letters, Vol. 18, No. 9, 01.05.2008, p. 2982-2984.

    Research output: Contribution to journalArticle

    Nakao, Youichi ; Narazaki, Genta ; Hoshino, Takuhiro ; Maeda, Satoko ; Yoshida, Minoru ; Maejima, Hiroshi ; Yamashita, Jun K. / Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells. In: Bioorganic and Medicinal Chemistry Letters. 2008 ; Vol. 18, No. 9. pp. 2982-2984.
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