Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells

Yoichi Nakao; Genta Narazaki; Takuhiro Hoshino; Satoko Maeda; Minoru Yoshida; Hiroshi Maejima; Jun K. Yamashita

doi:10.1016/j.bmcl.2008.03.053

Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells

Yoichi Nakao^*, Genta Narazaki, Takuhiro Hoshino, Satoko Maeda, Minoru Yoshida, Hiroshi Maejima, Jun K. Yamashita

^*Corresponding author for this work

School of Advanced Science and Engineering

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Evaluation of antiangiogenic activity of marine sponge derived azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells was carried out. Azumamide E (5) strongly inhibited in vitro angiogenesis from iPS cells at 1.9 μM while azumamide A (1) showed only weak inhibition at 19 μM. These results were well correlated with HDAC inhibitory activity of these compounds, revealing the prospect of azumamides as the probe molecules useful for stem cell chemical biology.

Original language	English
Pages (from-to)	2982-2984
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	18
Issue number	9
DOIs	https://doi.org/10.1016/j.bmcl.2008.03.053
Publication status	Published - 2008 May 1

Keywords

Angiogenesis
Chemical biology
Histone deacetylase
iPS cells

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/j.bmcl.2008.03.053

Cite this

@article{4f2ac866b22a40fb943b2b866e9bdd53,

title = "Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells",

abstract = "Evaluation of antiangiogenic activity of marine sponge derived azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells was carried out. Azumamide E (5) strongly inhibited in vitro angiogenesis from iPS cells at 1.9 μM while azumamide A (1) showed only weak inhibition at 19 μM. These results were well correlated with HDAC inhibitory activity of these compounds, revealing the prospect of azumamides as the probe molecules useful for stem cell chemical biology.",

keywords = "Angiogenesis, Chemical biology, Histone deacetylase, iPS cells",

author = "Yoichi Nakao and Genta Narazaki and Takuhiro Hoshino and Satoko Maeda and Minoru Yoshida and Hiroshi Maejima and Yamashita, {Jun K.}",

note = "Funding Information: This work was partly supported by the Waseda University Grant for Special Research Projects, the Nissui Research foundation, and a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan. ",

year = "2008",

month = may,

day = "1",

doi = "10.1016/j.bmcl.2008.03.053",

language = "English",

volume = "18",

pages = "2982--2984",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "9",

}

TY - JOUR

T1 - Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells

AU - Nakao, Yoichi

AU - Narazaki, Genta

AU - Hoshino, Takuhiro

AU - Maeda, Satoko

AU - Yoshida, Minoru

AU - Maejima, Hiroshi

AU - Yamashita, Jun K.

N1 - Funding Information: This work was partly supported by the Waseda University Grant for Special Research Projects, the Nissui Research foundation, and a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan.

PY - 2008/5/1

Y1 - 2008/5/1

N2 - Evaluation of antiangiogenic activity of marine sponge derived azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells was carried out. Azumamide E (5) strongly inhibited in vitro angiogenesis from iPS cells at 1.9 μM while azumamide A (1) showed only weak inhibition at 19 μM. These results were well correlated with HDAC inhibitory activity of these compounds, revealing the prospect of azumamides as the probe molecules useful for stem cell chemical biology.

AB - Evaluation of antiangiogenic activity of marine sponge derived azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells was carried out. Azumamide E (5) strongly inhibited in vitro angiogenesis from iPS cells at 1.9 μM while azumamide A (1) showed only weak inhibition at 19 μM. These results were well correlated with HDAC inhibitory activity of these compounds, revealing the prospect of azumamides as the probe molecules useful for stem cell chemical biology.

KW - Angiogenesis

KW - Chemical biology

KW - Histone deacetylase

KW - iPS cells

UR - http://www.scopus.com/inward/record.url?scp=42949139951&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=42949139951&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2008.03.053

DO - 10.1016/j.bmcl.2008.03.053

M3 - Article

C2 - 18397826

AN - SCOPUS:42949139951

VL - 18

SP - 2982

EP - 2984

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 9

ER -

Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this