Evaluation of antibacterial activity of zinc-doped hydroxyapatite colloids and dispersion stability using ultrasounds

Daniela Predoi, Simona Liliana Iconaru, Mihai Valentin Predoi, Mikael Motelica-Heino, Regis Guegan, Nicolas Buton

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

This study proves that the new developed zinc-doped hydroxyapatite (ZnHAp) colloids by an adapted sol-gel method can be widely used in the pharmaceutical, medical, and environmental industries. ZnHAp nanoparticles were stabilized in an aqueous solution, and their colloidal dispersions have been characterized by different techniques. Scanning Electron Microscopy (SEM) was used to get information on the morphology and composition of the investigated samples. Energy-dispersive X-ray spectroscopy (EDX) analysis confirmed the elemental compositions of ZnHAp colloidal dispersions. The homogeneous and uniform distribution of constituent elements (zinc, calcium, phosphorus, oxygen) was highlighted by the obtained elemental mapping results. The X-ray diffraction (XRD) results of the obtained samples showed a single phase corresponding to the hexagonal hydroxyapatite. The characteristic bands of the hydroxyapatite structure were also evidenced by Fourier-transform infrared spectroscopy (FTIR) analysis. For a stability assessment of the colloidal system, ζ-potential for the ZnHAp dispersions was estimated. Dynamic light scattering (DLS) was used to determine particles dispersion and hydrodynamic diameter (D HYD ). The goal of this study was to provide for the first time information on the stability of ZnHAp particles in solutions evaluated by non-destructive ultrasound-based technique. In this work, the influence of the ZnHAp colloidal solutions stability on the development of bacteria, such as Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), was also established for the first time. The antimicrobial activity of ZnHAp solutions was strongly influenced by both the stability of the solutions and the amount of Zn.

Original languageEnglish
Article number515
JournalNanomaterials
Volume9
Issue number4
DOIs
Publication statusPublished - 2019 Apr 1

Fingerprint

Colloids
Durapatite
Hydroxyapatite
Zinc
Ultrasonics
Dispersions
Dynamic light scattering
Chemical analysis
Chemical elements
Drug products
Phosphorus
Escherichia coli
Sol-gel process
Fourier transform infrared spectroscopy
Calcium
Bacteria
Hydrodynamics
Oxygen
Nanoparticles
X ray diffraction

Keywords

  • Antibacterial activity
  • Nanoparticles
  • Ultrasound technique
  • Zinc-doped hydroxyapatite

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Materials Science(all)

Cite this

Evaluation of antibacterial activity of zinc-doped hydroxyapatite colloids and dispersion stability using ultrasounds. / Predoi, Daniela; Iconaru, Simona Liliana; Predoi, Mihai Valentin; Motelica-Heino, Mikael; Guegan, Regis; Buton, Nicolas.

In: Nanomaterials, Vol. 9, No. 4, 515, 01.04.2019.

Research output: Contribution to journalArticle

Predoi, Daniela ; Iconaru, Simona Liliana ; Predoi, Mihai Valentin ; Motelica-Heino, Mikael ; Guegan, Regis ; Buton, Nicolas. / Evaluation of antibacterial activity of zinc-doped hydroxyapatite colloids and dispersion stability using ultrasounds. In: Nanomaterials. 2019 ; Vol. 9, No. 4.
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