Evaluation of photodynamic therapy in gastric cancer

Harubumi Kato, Minoru Kawaguchi, Chimori Konaka, Katsuaki Nishimiya, Norihiko Kawate, Kazuo Yoneyama, Komei Kinoshita, Masayuki Noguchi, Masanori Ishii, Masahiro Shirai, Takashi Hirano, Katsuo Aizawa, Yoshihiro Hayata

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Twenty-eight patients with gastric cancer were treated by photodynamic therapy. Haematoporphyrin derivative was used as a photosensitizer and an argon dye laser as a light source. Histologically, all tumours were adenocarcinomas. On the basis of endoscopy, 17 cases were categorized as early-stage cancer and were classified as type IIc (10 lesions), Ha (three lesions), combined type IIc and type III (three lesions) and type I (two lesions). In 11 patients with advanced-stage cancer, endoscopy showed one case of Borrmann I, three of Borrmann II, six of Borrmann III and a single case of Borrmann IV. In the 17 patients with early-stage cancers (18 lesions), complete remission was obtained in 10 patients (11 lesions). Of 13 resected cancers complete remission was confirmed in six lesions on the basis of detailed histological examination of resected specimens. In the advanced stage tumours all 11 patients showed incomplete remissions. It is considered that an incomplete response in the early-stage cancers is due to insufficient light dosage because of the wide area of tumour, because the site of the lesion is anatomically difficult to photoradiate and because the invasion extends to the muscular layer and serosa.

Original languageEnglish
Pages (from-to)67-74
Number of pages8
JournalLasers in Medical Science
Volume1
Issue number1
DOIs
Publication statusPublished - 1986 Jan
Externally publishedYes

Fingerprint

Photochemotherapy
Stomach Neoplasms
Neoplasms
Endoscopy
Hematoporphyrin Derivative
Dye Lasers
Light
Serous Membrane
Photosensitizing Agents
Argon
Adenocarcinoma

Keywords

  • Adenocarcinomas
  • Argon dye laser
  • Gastric cancer
  • Photodynamic therapy

ASJC Scopus subject areas

  • Surgery
  • Medicine (miscellaneous)

Cite this

Kato, H., Kawaguchi, M., Konaka, C., Nishimiya, K., Kawate, N., Yoneyama, K., ... Hayata, Y. (1986). Evaluation of photodynamic therapy in gastric cancer. Lasers in Medical Science, 1(1), 67-74. https://doi.org/10.1007/BF02030738

Evaluation of photodynamic therapy in gastric cancer. / Kato, Harubumi; Kawaguchi, Minoru; Konaka, Chimori; Nishimiya, Katsuaki; Kawate, Norihiko; Yoneyama, Kazuo; Kinoshita, Komei; Noguchi, Masayuki; Ishii, Masanori; Shirai, Masahiro; Hirano, Takashi; Aizawa, Katsuo; Hayata, Yoshihiro.

In: Lasers in Medical Science, Vol. 1, No. 1, 01.1986, p. 67-74.

Research output: Contribution to journalArticle

Kato, H, Kawaguchi, M, Konaka, C, Nishimiya, K, Kawate, N, Yoneyama, K, Kinoshita, K, Noguchi, M, Ishii, M, Shirai, M, Hirano, T, Aizawa, K & Hayata, Y 1986, 'Evaluation of photodynamic therapy in gastric cancer', Lasers in Medical Science, vol. 1, no. 1, pp. 67-74. https://doi.org/10.1007/BF02030738
Kato H, Kawaguchi M, Konaka C, Nishimiya K, Kawate N, Yoneyama K et al. Evaluation of photodynamic therapy in gastric cancer. Lasers in Medical Science. 1986 Jan;1(1):67-74. https://doi.org/10.1007/BF02030738
Kato, Harubumi ; Kawaguchi, Minoru ; Konaka, Chimori ; Nishimiya, Katsuaki ; Kawate, Norihiko ; Yoneyama, Kazuo ; Kinoshita, Komei ; Noguchi, Masayuki ; Ishii, Masanori ; Shirai, Masahiro ; Hirano, Takashi ; Aizawa, Katsuo ; Hayata, Yoshihiro. / Evaluation of photodynamic therapy in gastric cancer. In: Lasers in Medical Science. 1986 ; Vol. 1, No. 1. pp. 67-74.
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