Evaluation of the performance limit of MPPC for ToF-PET

Takayuki Tsujikawa, Jun Kataoka, Takahiro Ambe, Takuya Fujita, Yota Kurei, Goro Sato, Hirolazu Ikeda

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    In recent years, multi-pixel photon counters (MPPCs) have been actively studied for use in a module for such next-generation PET systems as MRI-PET, DoI-PET, and ToF-PET scanners. In particular, Time of Flight (ToF) measurement is a challenging approach to identify the position of a γ-ray source, according to differences in the arrival times of annihilation γ rays after positron decay. Several simulations suggest a substantial improvement in the signal-to-noise ratio of PET images when using ToF information. However, ToF-PET performance is determined by the time resolution of a γ-ray sensor (including scintillators, photo-sensors and readout electronics) as a whole, thus making it often difficult to achieve ToF resolution as good as 500 ps (FWHM) in actual PET systems. This paper describes our development of a new method of ToF measurement using MPPC-based scintillation detectors. We showed that our method effectively reduces the contamination of dark noise, and minimizes the effects of time walk and timing jitter. The best ToF resolution of 213 ps (FWHM) was achieved by coupling 3×3×10 mm3 Ce:LYSO crystal with a 3×3 mm2 pixel detector. We conclude by commenting on our ultra-fast ASIC for 16-ch MPPC readout as pertaining to future applications in MPPC-PET scanners with ToF measurement capability.

    Original languageEnglish
    Title of host publication2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014
    PublisherInstitute of Electrical and Electronics Engineers Inc.
    ISBN (Print)9781479960972
    DOIs
    Publication statusPublished - 2016 Mar 10
    EventIEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014 - Seattle, United States
    Duration: 2014 Nov 82014 Nov 15

    Other

    OtherIEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014
    CountryUnited States
    CitySeattle
    Period14/11/814/11/15

    Fingerprint

    Photons
    counters
    pixels
    evaluation
    photons
    rays
    scanners
    readout
    Scintillation Counting
    Signal-To-Noise Ratio
    flight characteristics
    application specific integrated circuits
    sensors
    detectors
    Noise
    scintillation counters
    scintillation
    arrivals
    Electrons
    positrons

    ASJC Scopus subject areas

    • Nuclear and High Energy Physics
    • Radiology Nuclear Medicine and imaging

    Cite this

    Tsujikawa, T., Kataoka, J., Ambe, T., Fujita, T., Kurei, Y., Sato, G., & Ikeda, H. (2016). Evaluation of the performance limit of MPPC for ToF-PET. In 2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014 [7430884] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NSSMIC.2014.7430884

    Evaluation of the performance limit of MPPC for ToF-PET. / Tsujikawa, Takayuki; Kataoka, Jun; Ambe, Takahiro; Fujita, Takuya; Kurei, Yota; Sato, Goro; Ikeda, Hirolazu.

    2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014. Institute of Electrical and Electronics Engineers Inc., 2016. 7430884.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Tsujikawa, T, Kataoka, J, Ambe, T, Fujita, T, Kurei, Y, Sato, G & Ikeda, H 2016, Evaluation of the performance limit of MPPC for ToF-PET. in 2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014., 7430884, Institute of Electrical and Electronics Engineers Inc., IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014, Seattle, United States, 14/11/8. https://doi.org/10.1109/NSSMIC.2014.7430884
    Tsujikawa T, Kataoka J, Ambe T, Fujita T, Kurei Y, Sato G et al. Evaluation of the performance limit of MPPC for ToF-PET. In 2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014. Institute of Electrical and Electronics Engineers Inc. 2016. 7430884 https://doi.org/10.1109/NSSMIC.2014.7430884
    Tsujikawa, Takayuki ; Kataoka, Jun ; Ambe, Takahiro ; Fujita, Takuya ; Kurei, Yota ; Sato, Goro ; Ikeda, Hirolazu. / Evaluation of the performance limit of MPPC for ToF-PET. 2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014. Institute of Electrical and Electronics Engineers Inc., 2016.
    @inproceedings{8d60b37b5d8c4f8ba12d0028bab1dd25,
    title = "Evaluation of the performance limit of MPPC for ToF-PET",
    abstract = "In recent years, multi-pixel photon counters (MPPCs) have been actively studied for use in a module for such next-generation PET systems as MRI-PET, DoI-PET, and ToF-PET scanners. In particular, Time of Flight (ToF) measurement is a challenging approach to identify the position of a γ-ray source, according to differences in the arrival times of annihilation γ rays after positron decay. Several simulations suggest a substantial improvement in the signal-to-noise ratio of PET images when using ToF information. However, ToF-PET performance is determined by the time resolution of a γ-ray sensor (including scintillators, photo-sensors and readout electronics) as a whole, thus making it often difficult to achieve ToF resolution as good as 500 ps (FWHM) in actual PET systems. This paper describes our development of a new method of ToF measurement using MPPC-based scintillation detectors. We showed that our method effectively reduces the contamination of dark noise, and minimizes the effects of time walk and timing jitter. The best ToF resolution of 213 ps (FWHM) was achieved by coupling 3×3×10 mm3 Ce:LYSO crystal with a 3×3 mm2 pixel detector. We conclude by commenting on our ultra-fast ASIC for 16-ch MPPC readout as pertaining to future applications in MPPC-PET scanners with ToF measurement capability.",
    author = "Takayuki Tsujikawa and Jun Kataoka and Takahiro Ambe and Takuya Fujita and Yota Kurei and Goro Sato and Hirolazu Ikeda",
    year = "2016",
    month = "3",
    day = "10",
    doi = "10.1109/NSSMIC.2014.7430884",
    language = "English",
    isbn = "9781479960972",
    booktitle = "2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014",
    publisher = "Institute of Electrical and Electronics Engineers Inc.",

    }

    TY - GEN

    T1 - Evaluation of the performance limit of MPPC for ToF-PET

    AU - Tsujikawa, Takayuki

    AU - Kataoka, Jun

    AU - Ambe, Takahiro

    AU - Fujita, Takuya

    AU - Kurei, Yota

    AU - Sato, Goro

    AU - Ikeda, Hirolazu

    PY - 2016/3/10

    Y1 - 2016/3/10

    N2 - In recent years, multi-pixel photon counters (MPPCs) have been actively studied for use in a module for such next-generation PET systems as MRI-PET, DoI-PET, and ToF-PET scanners. In particular, Time of Flight (ToF) measurement is a challenging approach to identify the position of a γ-ray source, according to differences in the arrival times of annihilation γ rays after positron decay. Several simulations suggest a substantial improvement in the signal-to-noise ratio of PET images when using ToF information. However, ToF-PET performance is determined by the time resolution of a γ-ray sensor (including scintillators, photo-sensors and readout electronics) as a whole, thus making it often difficult to achieve ToF resolution as good as 500 ps (FWHM) in actual PET systems. This paper describes our development of a new method of ToF measurement using MPPC-based scintillation detectors. We showed that our method effectively reduces the contamination of dark noise, and minimizes the effects of time walk and timing jitter. The best ToF resolution of 213 ps (FWHM) was achieved by coupling 3×3×10 mm3 Ce:LYSO crystal with a 3×3 mm2 pixel detector. We conclude by commenting on our ultra-fast ASIC for 16-ch MPPC readout as pertaining to future applications in MPPC-PET scanners with ToF measurement capability.

    AB - In recent years, multi-pixel photon counters (MPPCs) have been actively studied for use in a module for such next-generation PET systems as MRI-PET, DoI-PET, and ToF-PET scanners. In particular, Time of Flight (ToF) measurement is a challenging approach to identify the position of a γ-ray source, according to differences in the arrival times of annihilation γ rays after positron decay. Several simulations suggest a substantial improvement in the signal-to-noise ratio of PET images when using ToF information. However, ToF-PET performance is determined by the time resolution of a γ-ray sensor (including scintillators, photo-sensors and readout electronics) as a whole, thus making it often difficult to achieve ToF resolution as good as 500 ps (FWHM) in actual PET systems. This paper describes our development of a new method of ToF measurement using MPPC-based scintillation detectors. We showed that our method effectively reduces the contamination of dark noise, and minimizes the effects of time walk and timing jitter. The best ToF resolution of 213 ps (FWHM) was achieved by coupling 3×3×10 mm3 Ce:LYSO crystal with a 3×3 mm2 pixel detector. We conclude by commenting on our ultra-fast ASIC for 16-ch MPPC readout as pertaining to future applications in MPPC-PET scanners with ToF measurement capability.

    UR - http://www.scopus.com/inward/record.url?scp=84965064409&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84965064409&partnerID=8YFLogxK

    U2 - 10.1109/NSSMIC.2014.7430884

    DO - 10.1109/NSSMIC.2014.7430884

    M3 - Conference contribution

    SN - 9781479960972

    BT - 2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014

    PB - Institute of Electrical and Electronics Engineers Inc.

    ER -