Evolutionary conservation and conversion of Foxg1 function in brain development

Takuma Kumamoto, Carina Hanashima

    Research output: Contribution to journalReview article

    12 Citations (Scopus)

    Abstract

    Among the forkhead box protein family, Foxg1 is a unique transcription factor that plays pleiotropic and non-redundant roles in vertebrate brain development. The emergence of the telencephalon at the rostral end of the neural tube and its subsequent expansion that is mediated by Foxg1 was a key reason for the vertebrate brain to acquire higher order information processing, where Foxg1 is repetitively used in the sequential events of telencephalic development to control multi-steps of brain circuit formation ranging from cell cycle control to neuronal differentiation in a clade- and species-specific manner. The objective of this review is to discuss how the evolutionary changes in cis- and trans-regulatory network that is mediated by a single transcription factor has contributed to determining the fundamental vertebrate brain structure and its divergent roles in instructing species-specific neuronal circuitry and functional specialization.

    Original languageEnglish
    Pages (from-to)258-269
    Number of pages12
    JournalDevelopment Growth and Differentiation
    Volume59
    Issue number4
    DOIs
    Publication statusPublished - 2017 May 1

    Fingerprint

    Vertebrates
    Telencephalon
    Brain
    Transcription Factors
    Forkhead Transcription Factors
    Neural Tube
    Cell Cycle Checkpoints
    Automatic Data Processing

    Keywords

    • cerebrum
    • development
    • evolution
    • Foxg1
    • telencephalon
    • transcriptional regulation

    ASJC Scopus subject areas

    • Developmental Biology
    • Cell Biology

    Cite this

    Evolutionary conservation and conversion of Foxg1 function in brain development. / Kumamoto, Takuma; Hanashima, Carina.

    In: Development Growth and Differentiation, Vol. 59, No. 4, 01.05.2017, p. 258-269.

    Research output: Contribution to journalReview article

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