Ex vivo evaluation of high-intensity focused ultrasound with ultrasonic-induced cavitation bubbles

Nobutaka Abe, Hidekazu Nakamoto, Takashi Suzuki, Yoshihiro Muragaki, Hiroshi Iseki

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Abstract

    Purpose: In high-intensity focused ultrasound (HIFU) comprising high-intensity burst ultrasound (triggering pulse) and medium-intensity continuous wave ultrasound (heating wave), optimizing the effects of the triggering pulse conditions on the coagulated volume may help to reduce treatment times. Methods: HIFU combined with a triggering pulse was applied to chicken deep pectoral muscles. The acoustic power of the heating wave was set to 36, 54, or 72 W. Four different triggering pulse conditions were used: heating wave only; or pulse widths and pulse repetition frequencies of 30 μs and 1 kHz, 300 μs, and 100 Hz, or 3 ms and 10 Hz. Results: Compared to the heating wave only condition, the coagulated volume was significantly larger under all conditions that included a triggering pulse. Significant differences were also observed in the ellipticity of the coagulated region between some conditions. Conclusion: HIFU combined with a triggering pulse may play an important role in reducing treatment times.

    Original languageEnglish
    Pages (from-to)3-9
    Number of pages7
    JournalJournal of Medical Ultrasonics
    Volume41
    Issue number1
    DOIs
    Publication statusPublished - 2014 Jan 1

    Keywords

    • Cavitation bubbles
    • High-intensity focused ultrasound (HIFU)
    • High-intensity therapeutic ultrasound (HITU)

    ASJC Scopus subject areas

    • Radiology Nuclear Medicine and imaging

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