Exercise and Hormesis

Zsolt Radak*, Albert W. Taylor

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Citations (Scopus)


Exercise has systemic effects on the total body, despite varying blood flow and energy supply to different organs. VO2max, which is used as a marker for the cardiovascular system, is inversely proportional to mortality, and it is one of the best predictors of health. A single bout of exercise increases the level of reactive oxygen species (ROS) in an intensity-dependent manner, while regular exercise decreases ROS levels and oxidative damage. The effects of exercise on housekeeping systems are significant because it optimizes autophagy, mitophagy, and the repair systems of lipids, proteins, and DNA. Upregulation of the housekeeping systems results in enhanced cellular and organ function. Regular exercise can attenuate the aging process, and decrease the incidence of neurodegenerative, cardiovascular, and metabolic diseases, certain types of cancer, and sarcopenia.

Original languageEnglish
Title of host publicationThe Science of Hormesis in Health and Longevity
Number of pages11
ISBN (Electronic)9780128142530
ISBN (Print)9780128142547
Publication statusPublished - 2019 Jan 1
Externally publishedYes


  • adaptation
  • Aerobic exercise
  • age-associated diseases
  • hormesis
  • reactive oxygen species
  • resistance exercise

ASJC Scopus subject areas

  • Medicine(all)


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