Abstract
Exercise has systemic effects on the total body, despite varying blood flow and energy supply to different organs. VO2max, which is used as a marker for the cardiovascular system, is inversely proportional to mortality, and it is one of the best predictors of health. A single bout of exercise increases the level of reactive oxygen species (ROS) in an intensity-dependent manner, while regular exercise decreases ROS levels and oxidative damage. The effects of exercise on housekeeping systems are significant because it optimizes autophagy, mitophagy, and the repair systems of lipids, proteins, and DNA. Upregulation of the housekeeping systems results in enhanced cellular and organ function. Regular exercise can attenuate the aging process, and decrease the incidence of neurodegenerative, cardiovascular, and metabolic diseases, certain types of cancer, and sarcopenia.
| Original language | English |
|---|---|
| Title of host publication | The Science of Hormesis in Health and Longevity |
| Publisher | Elsevier |
| Pages | 63-73 |
| Number of pages | 11 |
| ISBN (Electronic) | 9780128142530 |
| ISBN (Print) | 9780128142547 |
| DOIs | |
| Publication status | Published - 2019 Jan 1 |
| Externally published | Yes |
Keywords
- adaptation
- Aerobic exercise
- age-associated diseases
- hormesis
- reactive oxygen species
- resistance exercise
ASJC Scopus subject areas
- Medicine(all)
