Exercise and hormesis: Oxidative stress-related adaptation for successful aging

Zsolt Radak, Hae Young Chung, Sataro Goto

Research output: Contribution to journalReview article

230 Citations (Scopus)

Abstract

The hormesis theory purports that biological systems respond with a bell-shaped curve to exposure to chemicals, toxins, and radiation. Here we extend the hormesis theory to include reactive oxygen species (ROS). We further suggest that the beneficial effects of regular exercise are partly based on the ROS generating capability of exercise, which is in the stimulation range of ROS production. Therefore, we suggest that exercise-induced ROS production plays a role in the induction of antioxidants, DNA repair and protein degrading enzymes, resulting in decreases in the incidence of oxidative stress-related diseases and retardation of the aging process.

Original languageEnglish
Pages (from-to)71-75
Number of pages5
JournalBiogerontology
Volume6
Issue number1
DOIs
Publication statusPublished - 2005 Jan 1
Externally publishedYes

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Keywords

  • Anti-oxidants
  • DNA repair
  • Exercise
  • Hormesis
  • Oxygen reactive species (ROS)

ASJC Scopus subject areas

  • Ageing
  • Gerontology
  • Geriatrics and Gerontology

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