Exercise causes tissue-specific enhancement of endothelin-1 mRNA expression in internal organs

Seiji Maeda, Takashi Miyauchi*, Tsutomu Kobayashi, Katsutoshi Goto, Mitsuo Matsuda

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

Endothelin-1 (ET-1) is a potent vasoconstrictor peptide, which also potentiates contractions to norepinephrine in human internal mammary and coronary vessels. Exercise causes a redistribution of blood flow, i.e., the increase in working muscles that is partly attributable to a decrease in visceral blood flow. We hypothesized that exercise causes a tissue-specific increase in ET-1 expression in internal organs. We studied whether exercise affects expression of preproET-1 mRNA in the kidneys and lungs. The rats performed treadmill running (0% grade) for 45 min at a speed of 25 m/min. The plasma concentrations of ET-1, epinephrine, and norepinephrine were greater in the exercise rats than in the sedentary control rats. The expression of preproET-1 mRNA in the kidneys was markedly higher in the exercise rats than in the sedentary control rats, whereas that in the lungs did not differ between the two groups. Therefore, the present study provides a possibility that the exercise-induced increase in production of ET-1 in the kidneys causes vasoconstriction and hence decreases blood flow in the kidneys through its direct vasoconstrictive action and/or its indirect effect of enhancing vasoconstrictions to norepinephrine.

Original languageEnglish
Pages (from-to)425-431
Number of pages7
JournalJournal of Applied Physiology
Volume85
Issue number2
DOIs
Publication statusPublished - 1998 Aug
Externally publishedYes

Keywords

  • Kidney
  • Lung
  • Preproendothelin-1 mRNA
  • Splanchnic circulation
  • Treadmill running

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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