Exercise combined with a probiotics treatment alters the microbiome, but moderately affects signalling pathways in the liver of male APP/PS1 transgenic mice

Tímea Téglás; Dóra Ábrahám; Mátyás Jókai; Saki Kondo; Rezieh Mohammadi; János Fehér; Dóra Szabó; Marta Wilhelm; Zsolt Radák

doi:10.1007/s10522-020-09895-7

Exercise combined with a probiotics treatment alters the microbiome, but moderately affects signalling pathways in the liver of male APP/PS1 transgenic mice

Tímea Téglás, Dóra Ábrahám, Mátyás Jókai, Saki Kondo, Rezieh Mohammadi, János Fehér, Dóra Szabó, Marta Wilhelm, Zsolt Radák^*

^*Corresponding author for this work

Graduate School of Sport Sciences

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

It has been demonstrated that physical exercise and probiotic supplementation delay the progress of Alzheimer’s Disease (AD) in male APP/PS1^TG mice. However, it has also been suggested that both exercise and AD have systemic effects. We have studied the effects of exercise training and probiotic treatment on microbiome and biochemical signalling proteins in the liver. The results suggest that liver is under oxidative stress, since SOD2 levels of APP/PS1 mice were decreased when compared to a wild type of mice. Exercise training prevented this decrease. We did not find significant changes in COX4, SIRT3, PGC-1a or GLUT4 levels, while the changes in pAMPK/AMPK, pmTOR/mTOR, pS6/S6 and NRF2 levels were randomly modulated. The data suggest that exercise and probiotics-induced changes in microbiome do not strongly affect mitochondrial density or protein synthesis-related AMPK/mTOR/S6 pathways in the liver of these animals.

Original language	English
Pages (from-to)	807-815
Number of pages	9
Journal	Biogerontology
Volume	21
Issue number	6
DOIs	https://doi.org/10.1007/s10522-020-09895-7
Publication status	Published - 2020 Dec 1

Keywords

Alzheimer’s disease
Exercise
Liver
Metabolism
Microbiome
Probiotics

ASJC Scopus subject areas

Ageing
Gerontology
Geriatrics and Gerontology

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title = "Exercise combined with a probiotics treatment alters the microbiome, but moderately affects signalling pathways in the liver of male APP/PS1 transgenic mice",

abstract = "It has been demonstrated that physical exercise and probiotic supplementation delay the progress of Alzheimer{\textquoteright}s Disease (AD) in male APP/PS1TG mice. However, it has also been suggested that both exercise and AD have systemic effects. We have studied the effects of exercise training and probiotic treatment on microbiome and biochemical signalling proteins in the liver. The results suggest that liver is under oxidative stress, since SOD2 levels of APP/PS1 mice were decreased when compared to a wild type of mice. Exercise training prevented this decrease. We did not find significant changes in COX4, SIRT3, PGC-1a or GLUT4 levels, while the changes in pAMPK/AMPK, pmTOR/mTOR, pS6/S6 and NRF2 levels were randomly modulated. The data suggest that exercise and probiotics-induced changes in microbiome do not strongly affect mitochondrial density or protein synthesis-related AMPK/mTOR/S6 pathways in the liver of these animals.",

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author = "T{\'i}mea T{\'e}gl{\'a}s and D{\'o}ra {\'A}brah{\'a}m and M{\'a}ty{\'a}s J{\'o}kai and Saki Kondo and Rezieh Mohammadi and J{\'a}nos Feh{\'e}r and D{\'o}ra Szab{\'o} and Marta Wilhelm and Zsolt Rad{\'a}k",

note = "Funding Information: This study was supported by OTKA (112810) and National Excellence Program (126823), and Scientific Excellence Program TUDFO/51757/2019-ITM, at the University of Physical Education, Innovation and Technology Ministry, Hungary. Grants awarded to Z.R. Publisher Copyright: {\textcopyright} 2020, The Author(s).",

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doi = "10.1007/s10522-020-09895-7",

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T1 - Exercise combined with a probiotics treatment alters the microbiome, but moderately affects signalling pathways in the liver of male APP/PS1 transgenic mice

AU - Téglás, Tímea

AU - Ábrahám, Dóra

AU - Jókai, Mátyás

AU - Kondo, Saki

AU - Mohammadi, Rezieh

AU - Fehér, János

AU - Szabó, Dóra

AU - Wilhelm, Marta

AU - Radák, Zsolt

N1 - Funding Information: This study was supported by OTKA (112810) and National Excellence Program (126823), and Scientific Excellence Program TUDFO/51757/2019-ITM, at the University of Physical Education, Innovation and Technology Ministry, Hungary. Grants awarded to Z.R. Publisher Copyright: © 2020, The Author(s).

PY - 2020/12/1

Y1 - 2020/12/1

N2 - It has been demonstrated that physical exercise and probiotic supplementation delay the progress of Alzheimer’s Disease (AD) in male APP/PS1TG mice. However, it has also been suggested that both exercise and AD have systemic effects. We have studied the effects of exercise training and probiotic treatment on microbiome and biochemical signalling proteins in the liver. The results suggest that liver is under oxidative stress, since SOD2 levels of APP/PS1 mice were decreased when compared to a wild type of mice. Exercise training prevented this decrease. We did not find significant changes in COX4, SIRT3, PGC-1a or GLUT4 levels, while the changes in pAMPK/AMPK, pmTOR/mTOR, pS6/S6 and NRF2 levels were randomly modulated. The data suggest that exercise and probiotics-induced changes in microbiome do not strongly affect mitochondrial density or protein synthesis-related AMPK/mTOR/S6 pathways in the liver of these animals.

AB - It has been demonstrated that physical exercise and probiotic supplementation delay the progress of Alzheimer’s Disease (AD) in male APP/PS1TG mice. However, it has also been suggested that both exercise and AD have systemic effects. We have studied the effects of exercise training and probiotic treatment on microbiome and biochemical signalling proteins in the liver. The results suggest that liver is under oxidative stress, since SOD2 levels of APP/PS1 mice were decreased when compared to a wild type of mice. Exercise training prevented this decrease. We did not find significant changes in COX4, SIRT3, PGC-1a or GLUT4 levels, while the changes in pAMPK/AMPK, pmTOR/mTOR, pS6/S6 and NRF2 levels were randomly modulated. The data suggest that exercise and probiotics-induced changes in microbiome do not strongly affect mitochondrial density or protein synthesis-related AMPK/mTOR/S6 pathways in the liver of these animals.

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Exercise combined with a probiotics treatment alters the microbiome, but moderately affects signalling pathways in the liver of male APP/PS1 transgenic mice

Abstract

Keywords

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