Exercise plays a preventive role against Alzheimer's disease

Zsolt Radak, Nikoletta Hart, Linda Sarga, Erika Koltai, Mustafa Atalay, Hideki Ohno, Istvan Boldogh

Research output: Contribution to journalReview article

168 Citations (Scopus)

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting the elderly population. It is predicted that the incidence of AD will be increased in the future making this disease one of the greatest medical, social, and economic challenges for individuals, families, and the health care system worldwide. The etiology of AD is multifactorial. It features increased oxidative state and deposition of amyloid plaques and neurofibrillary tangles of protein tau in the central cortex and limbic system of the brain. Here we provide an overview of the positive impacts of exercise on this challenging disease. Regular physical activity increases the endurance of cells and tissues to oxidative stress, vascularization, energy metabolism, and neurotrophin synthesis, all important in neurogenesis, memory improvement, and brain plasticity. Although extensive studies are required to understand the mechanism, it is clear that physical exercise is beneficial in the prevention of AD and other age-associated neurodegenerative disorders.

Original languageEnglish
Pages (from-to)777-783
Number of pages7
JournalJournal of Alzheimer's Disease
Volume20
Issue number3
DOIs
Publication statusPublished - 2010 Jan 1
Externally publishedYes

Keywords

  • Amyloid-β
  • amyloid-β degradation
  • exercise
  • metabolism
  • neurotrophins
  • physical inactivity
  • sirtuins

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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  • Cite this

    Radak, Z., Hart, N., Sarga, L., Koltai, E., Atalay, M., Ohno, H., & Boldogh, I. (2010). Exercise plays a preventive role against Alzheimer's disease. Journal of Alzheimer's Disease, 20(3), 777-783. https://doi.org/10.3233/JAD-2010-091531