TY - JOUR
T1 - Exercise training decreases expression of inflammation-related adipokines through reduction of oxidative stress in rat white adipose tissue
AU - Sakurai, Takuya
AU - Izawa, Tetsuya
AU - Kizaki, Takako
AU - Ogasawara, Jun etsu
AU - Shirato, Ken
AU - Imaizumi, Kazuhiko
AU - Takahashi, Kazuto
AU - Ishida, Hitoshi
AU - Ohno, Hideki
PY - 2009/2/6
Y1 - 2009/2/6
N2 - Increased oxidative stress in adipocytes causes dysregulated expression of inflammation-related adipokines. We have examined the effects of exercise training on oxidative stress in rat white adipose tissue (WAT), especially focusing on inflammation-related adipokines. The levels of lipid peroxidation in WAT of exercise-trained (TR) rats were lower than those in control (C) rats. The content of manganese-containing superoxide dismutase in WAT of TR rats was increased as compared with those in C rats. In contrast, the expression of the NADPH oxidase NOX2 protein in WAT was downregulated by exercise training. Moreover, the levels of inflammation-related adipokines, such as tumor necrosis factor-α and monocyte chemoattractant protein-1, in WAT of TR rats were lower than those in C rats. The effects of exercise training were more remarkable in visceral WAT than in subcutaneous. These results suggest that exercise training decreases the expression of inflammation-related adipokines by reducing oxidative stress in WAT.
AB - Increased oxidative stress in adipocytes causes dysregulated expression of inflammation-related adipokines. We have examined the effects of exercise training on oxidative stress in rat white adipose tissue (WAT), especially focusing on inflammation-related adipokines. The levels of lipid peroxidation in WAT of exercise-trained (TR) rats were lower than those in control (C) rats. The content of manganese-containing superoxide dismutase in WAT of TR rats was increased as compared with those in C rats. In contrast, the expression of the NADPH oxidase NOX2 protein in WAT was downregulated by exercise training. Moreover, the levels of inflammation-related adipokines, such as tumor necrosis factor-α and monocyte chemoattractant protein-1, in WAT of TR rats were lower than those in C rats. The effects of exercise training were more remarkable in visceral WAT than in subcutaneous. These results suggest that exercise training decreases the expression of inflammation-related adipokines by reducing oxidative stress in WAT.
KW - Exercise training
KW - Inflammation-related adipokines
KW - NADPH oxidase
KW - Oxidative stress
KW - Superoxide dismutase
KW - White adipose tissue
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U2 - 10.1016/j.bbrc.2008.12.127
DO - 10.1016/j.bbrc.2008.12.127
M3 - Article
C2 - 19121629
AN - SCOPUS:58149516721
SN - 0006-291X
VL - 379
SP - 605
EP - 609
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -