Exercise training decreases expression of inflammation-related adipokines through reduction of oxidative stress in rat white adipose tissue

Takuya Sakurai, Tetsuya Izawa, Takako Kizaki, Jun etsu Ogasawara, Ken Shirato, Kazuhiko Imaizumi, Kazuto Takahashi, Hitoshi Ishida, Hideki Ohno

    Research output: Contribution to journalArticle

    42 Citations (Scopus)

    Abstract

    Increased oxidative stress in adipocytes causes dysregulated expression of inflammation-related adipokines. We have examined the effects of exercise training on oxidative stress in rat white adipose tissue (WAT), especially focusing on inflammation-related adipokines. The levels of lipid peroxidation in WAT of exercise-trained (TR) rats were lower than those in control (C) rats. The content of manganese-containing superoxide dismutase in WAT of TR rats was increased as compared with those in C rats. In contrast, the expression of the NADPH oxidase NOX2 protein in WAT was downregulated by exercise training. Moreover, the levels of inflammation-related adipokines, such as tumor necrosis factor-α and monocyte chemoattractant protein-1, in WAT of TR rats were lower than those in C rats. The effects of exercise training were more remarkable in visceral WAT than in subcutaneous. These results suggest that exercise training decreases the expression of inflammation-related adipokines by reducing oxidative stress in WAT.

    Original languageEnglish
    Pages (from-to)605-609
    Number of pages5
    JournalBiochemical and Biophysical Research Communications
    Volume379
    Issue number2
    DOIs
    Publication statusPublished - 2009 Feb 6

    Fingerprint

    White Adipose Tissue
    Adipokines
    Oxidative stress
    Rats
    Oxidative Stress
    Exercise
    Tissue
    Inflammation
    Intra-Abdominal Fat
    Chemokine CCL2
    NADPH Oxidase
    Manganese
    Adipocytes
    Lipid Peroxidation
    Superoxide Dismutase
    Down-Regulation
    Tumor Necrosis Factor-alpha
    Lipids

    Keywords

    • Exercise training
    • Inflammation-related adipokines
    • NADPH oxidase
    • Oxidative stress
    • Superoxide dismutase
    • White adipose tissue

    ASJC Scopus subject areas

    • Biochemistry
    • Biophysics
    • Cell Biology
    • Molecular Biology

    Cite this

    Exercise training decreases expression of inflammation-related adipokines through reduction of oxidative stress in rat white adipose tissue. / Sakurai, Takuya; Izawa, Tetsuya; Kizaki, Takako; Ogasawara, Jun etsu; Shirato, Ken; Imaizumi, Kazuhiko; Takahashi, Kazuto; Ishida, Hitoshi; Ohno, Hideki.

    In: Biochemical and Biophysical Research Communications, Vol. 379, No. 2, 06.02.2009, p. 605-609.

    Research output: Contribution to journalArticle

    Sakurai, Takuya ; Izawa, Tetsuya ; Kizaki, Takako ; Ogasawara, Jun etsu ; Shirato, Ken ; Imaizumi, Kazuhiko ; Takahashi, Kazuto ; Ishida, Hitoshi ; Ohno, Hideki. / Exercise training decreases expression of inflammation-related adipokines through reduction of oxidative stress in rat white adipose tissue. In: Biochemical and Biophysical Research Communications. 2009 ; Vol. 379, No. 2. pp. 605-609.
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