Exercise training decreases expression of inflammation-related adipokines through reduction of oxidative stress in rat white adipose tissue

Takuya Sakurai*, Tetsuya Izawa, Takako Kizaki, Jun etsu Ogasawara, Ken Shirato, Kazuhiko Imaizumi, Kazuto Takahashi, Hitoshi Ishida, Hideki Ohno

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    52 Citations (Scopus)

    Abstract

    Increased oxidative stress in adipocytes causes dysregulated expression of inflammation-related adipokines. We have examined the effects of exercise training on oxidative stress in rat white adipose tissue (WAT), especially focusing on inflammation-related adipokines. The levels of lipid peroxidation in WAT of exercise-trained (TR) rats were lower than those in control (C) rats. The content of manganese-containing superoxide dismutase in WAT of TR rats was increased as compared with those in C rats. In contrast, the expression of the NADPH oxidase NOX2 protein in WAT was downregulated by exercise training. Moreover, the levels of inflammation-related adipokines, such as tumor necrosis factor-α and monocyte chemoattractant protein-1, in WAT of TR rats were lower than those in C rats. The effects of exercise training were more remarkable in visceral WAT than in subcutaneous. These results suggest that exercise training decreases the expression of inflammation-related adipokines by reducing oxidative stress in WAT.

    Original languageEnglish
    Pages (from-to)605-609
    Number of pages5
    JournalBiochemical and Biophysical Research Communications
    Volume379
    Issue number2
    DOIs
    Publication statusPublished - 2009 Feb 6

    Keywords

    • Exercise training
    • Inflammation-related adipokines
    • NADPH oxidase
    • Oxidative stress
    • Superoxide dismutase
    • White adipose tissue

    ASJC Scopus subject areas

    • Biochemistry
    • Biophysics
    • Cell Biology
    • Molecular Biology

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