Abstract
Aging results in significant loss of mass and function of the skeletal muscle, which negatively impacts the quality of life. In this study we investigated whether aerobic exercise training has the potential to alter anabolic and catabolic pathways in the skeletal muscle. Five and twenty eight month old rats were used in the study. Aging resulted in decreased levels of follistatin/mTOR/Akt/Erk activation and increased myostatin/Murf1/2, proteasome subunits, and protein ubiquitination levels. In addition, TNF-α, reactive oxygen species (ROS), p53, and Bax levels were increased while Bcl-2 levels were decreased in the skeletal muscle of aged rats. Six weeks of exercise training at 60% of VO2max reversed the age-associated activation of catabolic and apoptotic pathways and increased anabolic signaling. The results suggest that the age-associated loss of muscle mass and cachexia could be due to the orchestrated down-regulation of anabolic and up-regulation of catabolic and pro-apoptotic processes. These metabolic changes can be attenuated by exercise training.
| Original language | English |
|---|---|
| Pages (from-to) | 9-14 |
| Number of pages | 6 |
| Journal | Experimental Gerontology |
| Volume | 67 |
| DOIs | |
| Publication status | Published - 2015 Jul 1 |
| Externally published | Yes |
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Keywords
- Aging
- Exercise
- Follistatin
- Myostatin
- Reactive oxygen species
- Skeletal muscle
ASJC Scopus subject areas
- Biochemistry
- Ageing
- Molecular Biology
- Genetics
- Endocrinology
- Cell Biology
Cite this
Exercise training increases anabolic and attenuates catabolic and apoptotic processes in aged skeletal muscle of male rats. / Ziaaldini, Mohammad Mosaferi; Koltai, Erika; Csende, Zsolt; Goto, Sataro; Boldogh, Istvan; Taylor, Albert W.; Radak, Zsolt.
In: Experimental Gerontology, Vol. 67, 01.07.2015, p. 9-14.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Exercise training increases anabolic and attenuates catabolic and apoptotic processes in aged skeletal muscle of male rats
AU - Ziaaldini, Mohammad Mosaferi
AU - Koltai, Erika
AU - Csende, Zsolt
AU - Goto, Sataro
AU - Boldogh, Istvan
AU - Taylor, Albert W.
AU - Radak, Zsolt
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Aging results in significant loss of mass and function of the skeletal muscle, which negatively impacts the quality of life. In this study we investigated whether aerobic exercise training has the potential to alter anabolic and catabolic pathways in the skeletal muscle. Five and twenty eight month old rats were used in the study. Aging resulted in decreased levels of follistatin/mTOR/Akt/Erk activation and increased myostatin/Murf1/2, proteasome subunits, and protein ubiquitination levels. In addition, TNF-α, reactive oxygen species (ROS), p53, and Bax levels were increased while Bcl-2 levels were decreased in the skeletal muscle of aged rats. Six weeks of exercise training at 60% of VO2max reversed the age-associated activation of catabolic and apoptotic pathways and increased anabolic signaling. The results suggest that the age-associated loss of muscle mass and cachexia could be due to the orchestrated down-regulation of anabolic and up-regulation of catabolic and pro-apoptotic processes. These metabolic changes can be attenuated by exercise training.
AB - Aging results in significant loss of mass and function of the skeletal muscle, which negatively impacts the quality of life. In this study we investigated whether aerobic exercise training has the potential to alter anabolic and catabolic pathways in the skeletal muscle. Five and twenty eight month old rats were used in the study. Aging resulted in decreased levels of follistatin/mTOR/Akt/Erk activation and increased myostatin/Murf1/2, proteasome subunits, and protein ubiquitination levels. In addition, TNF-α, reactive oxygen species (ROS), p53, and Bax levels were increased while Bcl-2 levels were decreased in the skeletal muscle of aged rats. Six weeks of exercise training at 60% of VO2max reversed the age-associated activation of catabolic and apoptotic pathways and increased anabolic signaling. The results suggest that the age-associated loss of muscle mass and cachexia could be due to the orchestrated down-regulation of anabolic and up-regulation of catabolic and pro-apoptotic processes. These metabolic changes can be attenuated by exercise training.
KW - Aging
KW - Exercise
KW - Follistatin
KW - Myostatin
KW - Reactive oxygen species
KW - Skeletal muscle
UR - http://www.scopus.com/inward/record.url?scp=84928730718&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84928730718&partnerID=8YFLogxK
U2 - 10.1016/j.exger.2015.04.008
DO - 10.1016/j.exger.2015.04.008
M3 - Article
C2 - 25910622
AN - SCOPUS:84928730718
VL - 67
SP - 9
EP - 14
JO - Experimental Gerontology
JF - Experimental Gerontology
SN - 0531-5565
ER -