Exogenous nicotinamide supplementation and moderate physical exercise can attenuate the aging process in skeletal muscle of rats

Melitta Pajk, Alexandra Cselko, Csaba Varga, Aniko Posa, Margareta Tokodi, Istvan Boldogh, Sataro Goto, Zsolt Radak

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Nicotinamide (NAM) could enhance the availability of NAD+ and be beneficial to cell function. However, NAM can inhibit the activities of SIRT1 and PARP. The effect of NAM supplementation on the aging process is not well known. In the present study exogenous NAM (1–0.5% in drinking water) was supplemented for 5 weeks and in the last 4 weeks moderate treadmill running was given to 5 mo and 28 mo old rats. The content of SIRT1 was not effected by NAM treatment alone. However, the activity of SIRT1, judged from the acetylated p53/p53 ratio, increased in both NAM treated age groups, suggesting beneficial effects of exogenous NAM. This was confirmed by the finding of increased PGC-1α and pCREB/CREB ratio in the gastrocnemius muscle of old but not young NAM treated animals. Our data suggest NAM administration can attenuate the aging process in skeletal muscle of rats, but NAM administration together with exercise training might be too great challenge to cope with in the old animals, since it leads to decreased levels of SIRT1.

Original languageEnglish
Pages (from-to)593-600
Number of pages8
JournalBiogerontology
Volume18
Issue number4
DOIs
Publication statusPublished - 2017 Aug 1
Externally publishedYes

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Keywords

  • Aging
  • Exercise
  • Nicotinamide
  • SIRT1

ASJC Scopus subject areas

  • Ageing
  • Gerontology
  • Geriatrics and Gerontology

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