Experimental Estimation of Primary and Secondary Nucleation Kinetics of Antisolvent Crystallization As Measured by Induction Time

Takanori Kodera, Masanori Kobari, Izumi Hirasawa

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Methodologies for the estimation of nucleation rate parameters, which are rate constants and orders in antisolvent crystallization, are proposed with the aim of applying to the pharmaceutical industry. Primary and secondary nucleations are clearly distinguished and these rates are defined as power laws of the supersaturation in our antisolvent crystallization model. Primary nucleation rate parameters were experimentally determined using the theoretical equation about the modified induction time in antisolvent crystallization based on the past study reported by Kubota, N. [ J. Cryst. Growth 2010, 312, 548-554 ], in which the induction time is defined as the time when the number density of the crystal reaches a fixed value. It is difficult to estimate the number density at the detection point using an experimental approach. Therefore, a numerical approach was used to determine the number density. The estimated number density at the detection point can determine the secondary nucleation rate parameters. These determined nucleation rate parameters become effective factors for simulating the number mean diameter in antisolvent crystallization and can be applied to the pharmaceutical industry.

Original languageEnglish
Pages (from-to)2724-2732
Number of pages9
JournalOrganic Process Research and Development
Volume23
Issue number12
DOIs
Publication statusPublished - 2019 Dec 20

Keywords

  • antisolvent crystallization
  • modified induction time
  • pharmaceutical industry
  • primary nucleation rate
  • secondary nucleation rate

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry

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