Exploring the importance of translational regulation in the inflammatory responses by a genome-wide approach

Hiroaki Sako, Katsuhiko Suzuki

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

It is widely recognized that exercise has an important role in inflammation regulation. To understand inflammatory mechanisms, extensive studies on the transcriptome and proteome have been conducted. However, interpreting these results is difficult, partly due to technical difficulties that impose some restriction on the accuracy and comprehensiveness of measurements. Here we first mention some limitations of studies involving large scale proteomics and high-throughput transcriptomics and further introduce a newly developed genome-wide translational analysis which may overcome some of the limitations and discover novel cellular dynamics. We then show preliminary results obtained by conducting a genome-wide translational analysis of the early inflammatory response of macrophages in response to lipopolysaccharide (LPS), and discuss the potential to identify novel factors by employing a genome-wide translational analysis.

Original languageEnglish
Pages (from-to)55-67
Number of pages13
JournalExercise immunology review
Volume20
Publication statusPublished - 2014 Jan 1

Keywords

  • Gene expression
  • Inflammation
  • Macrophages
  • Translational isoform
  • Translational regulation
  • Up stream open reading frame (uORF)

ASJC Scopus subject areas

  • Immunology

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