F 1-ATPase: A prototypical rotary molecular motor

Kazuhiko Kinosita

    Research output: Chapter in Book/Report/Conference proceedingChapter

    8 Citations (Scopus)

    Abstract

    F 1-ATPase, the soluble portion of ATP synthase, has been shown to be a rotary molecular motor in which the central γ subunit rotates inside the cylinder made of α 3β 3 subunits. The rotation is powered by ATP hydrolysis in three catalytic sites, and reverse rotation of the γ subunit by an external force leads to ATP synthesis in the catalytic sites. Here I look back how our lab became involved in the study of this marvelous rotary machine, and discuss some aspects of its rotary mechanism while confessing we are far from understanding. This article is a very personal essay, not a scientific review, for this otherwise viral machines book.

    Original languageEnglish
    Title of host publicationAdvances in Experimental Medicine and Biology
    Pages5-16
    Number of pages12
    Volume726
    DOIs
    Publication statusPublished - 2012

    Publication series

    NameAdvances in Experimental Medicine and Biology
    Volume726
    ISSN (Print)00652598

      Fingerprint

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)
    • Medicine(all)

    Cite this

    Kinosita, K. (2012). F 1-ATPase: A prototypical rotary molecular motor. In Advances in Experimental Medicine and Biology (Vol. 726, pp. 5-16). (Advances in Experimental Medicine and Biology; Vol. 726). https://doi.org/10.1007/978-1-4614-0980-9_2