F-substituted carbonate apatite for promoting bone formation

Yu Sogo, Daiki Yokoyama, Atsuo Ito, Atsushi Yamazaki, Racquel Z. LeGeros

    Research output: Contribution to journalArticle

    Abstract

    Fluoride (F)-substituted type-B carbonate-containing hydroxyapatites (CHAPs) were prepared as bone substitutes with a F-releasing ability. The F - contents in the F-substituted CHAPs were 16-22 times larger than that in normal adult human bones. The carbonate contents in the F-substituted CHAPs corresponded to that in human bones. The F-substituted CHAPs released F- in an acetic acid - sodium acetate buffer at pH 4.9; within only 3 h, the F- concentration in the buffer increased to more than 63.9 μg L-1, which was 1.5- 8.9 times higher than that in a body fluid of normal adult humans. Although the F- concentration rapidly decreased probably due to the precipitation of a certain phase containing F-, the F-substituted CHAPs exhibited the ability to increase the F- concentration in a body fluid by bone resorption. Therefore, it is expected that the F-substituted CHAPs will be feasible as a F-releasing material for promoting bone formation.

    Original languageEnglish
    Pages (from-to)141-144
    Number of pages4
    JournalKey Engineering Materials
    Volume309-311 I
    Publication statusPublished - 2006

    Fingerprint

    Hydroxyapatites
    Apatite
    Hydroxyapatite
    Carbonates
    Bone
    Body fluids
    Buffers
    Bone Substitutes
    Sodium Acetate
    Fluorides
    Acetic acid
    Acetic Acid
    carboapatite
    Sodium

    Keywords

    • Bone substitute
    • Carbonate-containing hydroxyapatite
    • Fluoride
    • Release property

    ASJC Scopus subject areas

    • Ceramics and Composites
    • Chemical Engineering (miscellaneous)

    Cite this

    Sogo, Y., Yokoyama, D., Ito, A., Yamazaki, A., & LeGeros, R. Z. (2006). F-substituted carbonate apatite for promoting bone formation. Key Engineering Materials, 309-311 I, 141-144.

    F-substituted carbonate apatite for promoting bone formation. / Sogo, Yu; Yokoyama, Daiki; Ito, Atsuo; Yamazaki, Atsushi; LeGeros, Racquel Z.

    In: Key Engineering Materials, Vol. 309-311 I, 2006, p. 141-144.

    Research output: Contribution to journalArticle

    Sogo, Y, Yokoyama, D, Ito, A, Yamazaki, A & LeGeros, RZ 2006, 'F-substituted carbonate apatite for promoting bone formation', Key Engineering Materials, vol. 309-311 I, pp. 141-144.
    Sogo Y, Yokoyama D, Ito A, Yamazaki A, LeGeros RZ. F-substituted carbonate apatite for promoting bone formation. Key Engineering Materials. 2006;309-311 I:141-144.
    Sogo, Yu ; Yokoyama, Daiki ; Ito, Atsuo ; Yamazaki, Atsushi ; LeGeros, Racquel Z. / F-substituted carbonate apatite for promoting bone formation. In: Key Engineering Materials. 2006 ; Vol. 309-311 I. pp. 141-144.
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    AB - Fluoride (F)-substituted type-B carbonate-containing hydroxyapatites (CHAPs) were prepared as bone substitutes with a F-releasing ability. The F - contents in the F-substituted CHAPs were 16-22 times larger than that in normal adult human bones. The carbonate contents in the F-substituted CHAPs corresponded to that in human bones. The F-substituted CHAPs released F- in an acetic acid - sodium acetate buffer at pH 4.9; within only 3 h, the F- concentration in the buffer increased to more than 63.9 μg L-1, which was 1.5- 8.9 times higher than that in a body fluid of normal adult humans. Although the F- concentration rapidly decreased probably due to the precipitation of a certain phase containing F-, the F-substituted CHAPs exhibited the ability to increase the F- concentration in a body fluid by bone resorption. Therefore, it is expected that the F-substituted CHAPs will be feasible as a F-releasing material for promoting bone formation.

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