Fabrication of free-standing nanoparticle-fused nanosheets and their hetero-modification using sacrificial film

Yosuke Okamura, Saori Utsunomiya, Hidenori Suzuki, Daisuke Niwa, Tetsuya Osaka, Shinji Takeoka

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Sheet-shaped carriers, having obverse and reverse surfaces and thus a large contact area as a targeting site, have several advantages over spherical-shaped carriers, which have an extremely small contact area. Herein is proposed a novel method for the preparation of free-standing nanoparticle-fused nanosheets having uniform micrometer shape, nanometer thickness and heterogenous surfaces, using a water-soluble sacrificial film. This was achieved by combination of four processes: (1) specific adsorption of latex beads at pH 5.0 and a concentration of 1.0 × 1011 mL-1 onto a patterned dodecyltrimethoxysilane self-assembled monolayer (DTS-SAM) region by a conventional dry patterning process, (2) fabrication of the latex bead-sheet via thermal-fusion at 110 °C for 60 s, (3) preparation of the free-standing nanosheet by detachment from the DTS-SAM, and (4) hetero-modification of the resulting nanosheet using a water-soluble poly(acrylic acid) as a sacrificial supporting film. Thus, this sheet-shaped carrier having hetero-surfaces can be regarded as a new material for delivery of drugs, hemostatic reagents and as wound dressings for burn injury, etc.

Original languageEnglish
Pages (from-to)184-190
Number of pages7
JournalColloids and Surfaces A: Physicochemical and Engineering Aspects
Volume318
Issue number1-3
DOIs
Publication statusPublished - 2008 Apr 1

Fingerprint

Nanosheets
carbopol 940
Latex
Self assembled monolayers
Nanoparticles
latex
Latexes
Fabrication
beads
nanoparticles
fabrication
hemostatics
preparation
Water
acrylic acid
Hemostatics
detachment
water
Acrylics
reagents

Keywords

  • Free-standing
  • Hetero-modification
  • Nanosheet
  • Sacrificial film
  • Thermal fusion

ASJC Scopus subject areas

  • Colloid and Surface Chemistry
  • Physical and Theoretical Chemistry

Cite this

Fabrication of free-standing nanoparticle-fused nanosheets and their hetero-modification using sacrificial film. / Okamura, Yosuke; Utsunomiya, Saori; Suzuki, Hidenori; Niwa, Daisuke; Osaka, Tetsuya; Takeoka, Shinji.

In: Colloids and Surfaces A: Physicochemical and Engineering Aspects, Vol. 318, No. 1-3, 01.04.2008, p. 184-190.

Research output: Contribution to journalArticle

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