TY - JOUR
T1 - Fabrication of hyaluronic acid hollow microneedle array
AU - Terashima, Shingo
AU - Tatsukawa, Chikako
AU - Takahashi, Tomokazu
AU - Suzuki, Masato
AU - Aoyagi, Seiji
N1 - Publisher Copyright:
© 2020 The Japan Society of Applied Physics.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/6/1
Y1 - 2020/6/1
N2 - A hollow microneedles array using biodegradable hyaluronic acid as the material for the microneedle array was fabricated. We proposed a method in which gelatinous hyaluronic acid was affixed to a core and then released after drying. A polylactic acid which has high tensile strength and high affinity for hyaluronic acid was used as the core material. Using this method, we succeeded at fabricating a highly safe hollow microneedle array. An opening was formed in the needle tip by coating the tip of the core with a hydrophobic UV curable resin. The diameter of the needle tip could be reduced by using a conical core, and the needle tip was sharpened by cutting it with a femtosecond laser. The mechanical strength of hyaluronic acid hollow microneedle was evaluated using the surface of artificial skin.
AB - A hollow microneedles array using biodegradable hyaluronic acid as the material for the microneedle array was fabricated. We proposed a method in which gelatinous hyaluronic acid was affixed to a core and then released after drying. A polylactic acid which has high tensile strength and high affinity for hyaluronic acid was used as the core material. Using this method, we succeeded at fabricating a highly safe hollow microneedle array. An opening was formed in the needle tip by coating the tip of the core with a hydrophobic UV curable resin. The diameter of the needle tip could be reduced by using a conical core, and the needle tip was sharpened by cutting it with a femtosecond laser. The mechanical strength of hyaluronic acid hollow microneedle was evaluated using the surface of artificial skin.
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U2 - 10.35848/1347-4065/ab7312
DO - 10.35848/1347-4065/ab7312
M3 - Article
AN - SCOPUS:85083339913
VL - 59
JO - Japanese Journal of Applied Physics, Part 1: Regular Papers & Short Notes
JF - Japanese Journal of Applied Physics, Part 1: Regular Papers & Short Notes
SN - 0021-4922
IS - SI
M1 - SIIJ03
ER -