Fabrication of hyaluronic acid hollow microneedle array

Shingo Terashima, Chikako Tatsukawa, Tomokazu Takahashi, Masato Suzuki, Seiji Aoyagi

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


A hollow microneedles array using biodegradable hyaluronic acid as the material for the microneedle array was fabricated. We proposed a method in which gelatinous hyaluronic acid was affixed to a core and then released after drying. A polylactic acid which has high tensile strength and high affinity for hyaluronic acid was used as the core material. Using this method, we succeeded at fabricating a highly safe hollow microneedle array. An opening was formed in the needle tip by coating the tip of the core with a hydrophobic UV curable resin. The diameter of the needle tip could be reduced by using a conical core, and the needle tip was sharpened by cutting it with a femtosecond laser. The mechanical strength of hyaluronic acid hollow microneedle was evaluated using the surface of artificial skin.

Original languageEnglish
Article numberSIIJ03
JournalJapanese journal of applied physics
Issue numberSI
Publication statusPublished - 2020 Jun 1
Externally publishedYes

ASJC Scopus subject areas

  • Engineering(all)
  • Physics and Astronomy(all)


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