Fabrication of lipid tubules with embedded quantum dots by membrane tubulation protein

Masayoshi Tanaka, Kevin Critchley, Tadashi Matsunaga, Stephen D. Evans, Sarah S. Staniland

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The first one-dimensional (1D) assembly of low-toxicity CuInS 2/ZnS quantum dots (QDs) embedded in lipid nanotubules, formed from liposomes using the Amphiphysin-BAR (Bin-Amphiphysin-Rvs domain of human amphiphysin) protein to elongate the structure, is reported. The QD-containing lipid nanotubules display a high aspect ratio of ≈500:1 (≈40 nm diameter and 20 μm length) and are stable for more than 20 h. Furthermore, this methodology is extended to the assembly of various nanoparticle species within 1D lipid nanotubules, and includes materials such as CdSe and Au. Encapsulation within the hydrophobic core of the bilayer makes these materials highly biocompatible. The developed methodology and materials with these unique characteristics could be useful for various applications in nanobiotechnology and nanomedicine.

Original languageEnglish
Pages (from-to)1590-1595
Number of pages6
JournalSmall
Volume8
Issue number10
DOIs
Publication statusPublished - 2012 May 21
Externally publishedYes

Fingerprint

Quantum Dots
Lipids
Semiconductor quantum dots
Membrane Proteins
Proteins
Membranes
Fabrication
Nanobiotechnology
Nanomedicine
Medical nanotechnology
Liposomes
Biocompatible Materials
Bins
Encapsulation
Biomaterials
Nanoparticles
Toxicity
Aspect ratio
amphiphysin

Keywords

  • biocompatible materials
  • encapsulation
  • lipid tubules
  • nanoparticles
  • quantum dots

ASJC Scopus subject areas

  • Biomaterials
  • Engineering (miscellaneous)
  • Biotechnology
  • Medicine(all)

Cite this

Fabrication of lipid tubules with embedded quantum dots by membrane tubulation protein. / Tanaka, Masayoshi; Critchley, Kevin; Matsunaga, Tadashi; Evans, Stephen D.; Staniland, Sarah S.

In: Small, Vol. 8, No. 10, 21.05.2012, p. 1590-1595.

Research output: Contribution to journalArticle

Tanaka, Masayoshi ; Critchley, Kevin ; Matsunaga, Tadashi ; Evans, Stephen D. ; Staniland, Sarah S. / Fabrication of lipid tubules with embedded quantum dots by membrane tubulation protein. In: Small. 2012 ; Vol. 8, No. 10. pp. 1590-1595.
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