Fabrication, Properties, and Biomedical Applications of Nanosheets

Toshinori Fujie, Yosuke Okamura, Shinji Takeoka

Research output: Chapter in Book/Report/Conference proceedingChapter

11 Citations (Scopus)

Abstract

Nanosheets, ultrathin sheet-shaped materials, have several advantages in the biomedical field; a large contact area in the biointerface, noncovalent adhesion, small amount ofmaterial required, and dual surfaces for heterofunctionalization. In terms of a drug-delivery vehicle, the sheet-shaped carriers perform unique dynamic functions over spherically shaped carriers. For surgical dressing, the sheet-shaped materials can densely overlap the tissue defect site without the need for chemical adhesive reagents. In this review, we propose a methodology for the preparation of freestanding, ultrathin nanosheets with a huge aspect ratio and heterosurfaces, fabricated through molecular assembly. In their practical biomedical applications, the micrometer-sized nanosheet was constructed by exploiting a micropatterned substrate with a precisely controlled size, applicable for injectable sheet-shaped drug carriers, whereas the giant nanosheets, with an aspect ratio of >106, can act as novel biomaterials for surgical dressing in the next generation of minimally invasive treatments.

Original languageEnglish
Title of host publicationFunctional Polymer Films
PublisherWiley-VCH
Pages907-931
Number of pages25
Volume2
ISBN (Print)9783527321902
DOIs
Publication statusPublished - 2011 Jun 7

Keywords

  • Biomedical applications
  • Drug-delivery vehicle
  • Heterofunctionalization
  • Nanoadhesive plasters
  • Nanosheets
  • Platelet substitutes

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Materials Science(all)

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  • Cite this

    Fujie, T., Okamura, Y., & Takeoka, S. (2011). Fabrication, Properties, and Biomedical Applications of Nanosheets. In Functional Polymer Films (Vol. 2, pp. 907-931). Wiley-VCH. https://doi.org/10.1002/9783527638482.ch29