Abstract
Nanosheets, ultrathin sheet-shaped materials, have several advantages in the biomedical field; a large contact area in the biointerface, noncovalent adhesion, small amount ofmaterial required, and dual surfaces for heterofunctionalization. In terms of a drug-delivery vehicle, the sheet-shaped carriers perform unique dynamic functions over spherically shaped carriers. For surgical dressing, the sheet-shaped materials can densely overlap the tissue defect site without the need for chemical adhesive reagents. In this review, we propose a methodology for the preparation of freestanding, ultrathin nanosheets with a huge aspect ratio and heterosurfaces, fabricated through molecular assembly. In their practical biomedical applications, the micrometer-sized nanosheet was constructed by exploiting a micropatterned substrate with a precisely controlled size, applicable for injectable sheet-shaped drug carriers, whereas the giant nanosheets, with an aspect ratio of >106, can act as novel biomaterials for surgical dressing in the next generation of minimally invasive treatments.
Original language | English |
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Title of host publication | Functional Polymer Films |
Publisher | Wiley-VCH |
Pages | 907-931 |
Number of pages | 25 |
Volume | 2 |
ISBN (Print) | 9783527321902 |
DOIs | |
Publication status | Published - 2011 Jun 7 |
Keywords
- Biomedical applications
- Drug-delivery vehicle
- Heterofunctionalization
- Nanoadhesive plasters
- Nanosheets
- Platelet substitutes
ASJC Scopus subject areas
- Physics and Astronomy(all)
- Materials Science(all)