Facilitation of α-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor transmission in the suprachiasmatic nucleus by aniracetam enhances photic responses of the biological clock in rodents

Takahiro Moriya, Masayuki Ikeda, Koji Teshima, Reiko Hara, Koji Kuriyama, Tohru Yoshioka, Charles N. Allent, Shigenobu Shibata

    Research output: Contribution to journalArticle

    14 Citations (Scopus)

    Abstract

    This study was designed to test whether the α-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptor facilitating drug, aniracetam, could potentiate photic responses of the biological clock in the suprachiasmatic nucleus (SCN) of rodents. Using the whole-cell patch technique, we first demonstrated that AMPA currents elicited by either local AMPA application or optic chiasm stimulation were augmented by aniracetam in the neurons of the SCN. The AMPA application-elicited increase of intracellular Ca2+ concentration in SCN slices was also enhanced by aniracetam treatment. The systemic injection of aniracetam dosedependently (10-100 mg/kg) potentiated the phase delay in behavioral rhythm induced by brief light exposure of low intensity (3 lux) but not high intensity (10 or 60 lux) during early subjective night. Under the blockade of NMDA receptors by (+) MK801, aniracetam failed to potentiate a light (3 lux) induced phase delay in behavioral rhythm. Aniracetam increased the photic induction of c-Fos protein in the SCN that was elicited by low intensity light exposure (3 lux). These results suggest that AMPA receptor-mediated responses facilitated by aniracetam can explain enhanced photic responses of the biological clock in the SCN of rodents.

    Original languageEnglish
    Pages (from-to)978-987
    Number of pages10
    JournalJournal of Neurochemistry
    Volume85
    Issue number4
    Publication statusPublished - 2003 May

    Fingerprint

    aniracetam
    Biological Clocks
    Suprachiasmatic Nucleus
    Propionates
    Clocks
    Rodentia
    Light
    Proto-Oncogene Proteins c-fos
    Drug Receptors
    Optic Chiasm
    bucide
    N-Methyl-D-Aspartate Receptors
    Neurons

    Keywords

    • Behavioral rhythm
    • c-Fos protein
    • Ca imaging
    • Circadian rhythm
    • Whole-cell patch clamp

    ASJC Scopus subject areas

    • Biochemistry
    • Cellular and Molecular Neuroscience

    Cite this

    Facilitation of α-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor transmission in the suprachiasmatic nucleus by aniracetam enhances photic responses of the biological clock in rodents. / Moriya, Takahiro; Ikeda, Masayuki; Teshima, Koji; Hara, Reiko; Kuriyama, Koji; Yoshioka, Tohru; Allent, Charles N.; Shibata, Shigenobu.

    In: Journal of Neurochemistry, Vol. 85, No. 4, 05.2003, p. 978-987.

    Research output: Contribution to journalArticle

    Moriya, Takahiro ; Ikeda, Masayuki ; Teshima, Koji ; Hara, Reiko ; Kuriyama, Koji ; Yoshioka, Tohru ; Allent, Charles N. ; Shibata, Shigenobu. / Facilitation of α-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor transmission in the suprachiasmatic nucleus by aniracetam enhances photic responses of the biological clock in rodents. In: Journal of Neurochemistry. 2003 ; Vol. 85, No. 4. pp. 978-987.
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