Facilitatory effect of olfactory bulbectomy on 2-deoxyglucose uptake in rat amygdala slices

Shigenobu Shibata*, Shigenori Watanabe

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


The aim of the present study was to determine whether the 2-deoxyglucose uptake of amygdala slices was affected by olfactory bulbectomy. At 7, 14 and 21 days post-lesion, bilateral olfactory bulbectomized rats exhibited a significant increase of 2-deoxyglucose uptake in amygdala slices, but not in the cerebral cortex. In addition, unilateral olfactory bulbectomized rats showed a high uptake of 2-deoxyglucose uptake in the ipsilateral amygdala, but not in the contralateral amygdala. These results suggest that the enhancement of 2-deoxyglucose uptake is related to the hyperexcitability of amygdala neurons following bulbectomy, and that this enhancement may be responsible for the behavioral changes in olfactory bulbectomized rats.

Original languageEnglish
Pages (from-to)147-150
Number of pages4
JournalBrain Research
Issue number1
Publication statusPublished - 1994 Nov 28
Externally publishedYes


  • 2-Deoxyglucose
  • Amygdala
  • Brain slice
  • Cerebral cortex
  • Olfactory bulbectomy

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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