Facilitatory effect of vasopressin on the ischemic decrease of the CA1 presynaptic fiber spikes in rat hippocampal slices

Takeshi Tanaka, Yoshiyuki Shishido, Shigenobu Shibata, Shigenori Watanabe

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

We investigated the effects of vasopressin-related neuropeptides on the hypoxia/hypoglycemia (ischemia)-induced decrease of the CA1 potential presynaptic elicited by stimulation of Schaffer collaterals in rat hippocampal slices. Treatment with arginine-vasopressin (AVP) potentiated the ischemic decrease of the CA1 presynaptic potential. In contrast, a V1 receptor antagonist produced a dose-dependent neuroprotective effect, whereas a V2 receptor antagonist had no effect. The AVP-induced decrease of the CA1 presynaptic potential was completely blocked by simultaneous application of the V1 receptor antagonist. Because AVP4-9 is regarded as the major proteoplytic product of AVP in the rat brain, we examined its effect on the ischemic decrease of the CA1 presynaptic potential. Treatment with AVP4-9 produced a more marked reduction of the potential than treatment with AVP itself. The present study demonstrates that stimulation of the V1 receptor has a detrimental effect on the development of ihe ischemic damage whereas V1 receptor blockade has a neuroprotective effect, suggesting that AVP may potentiate ischemic neuronal deficits via V1 receptor stimulation.

Original languageEnglish
Pages (from-to)343-346
Number of pages4
JournalBrain Research
Volume644
Issue number2
DOIs
Publication statusPublished - 1994 May 2
Externally publishedYes

Keywords

  • Hippocampus
  • Hypoxia/hypoglycemia
  • Ischemia
  • Presynaptic potential
  • Vasopressin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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