Facilitatory effects of somatostatin on reduced uptake of 2-deoxyglucose in cerebral cortical and hippocampal slices from aged rats

Shibata Shigenobu Shibata, Tanaka Takeshi Tanaka, Watanabe Shigenori Watanabe

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The aim of the present study was to determine whether or not the reduction of 2-deoxyglucose uptake by the cerebral cortical slices in aged rats (22-23 months old) was attenuated by somatostatin or carbachol. In 8-week-old rats, somatostatin and carbachol produced concentration-dependent increases in 2-deoxyglucose uptake. 2-Deoxyglucose uptake of the cortical slices in 2-23-month-old rats was significantly facilitated by treatment with 0.1-1 ωM somatostatin or 1-100 ωM carbachol. Metabolic responses to somatostatin or carbachol were quite similar in young and aged rats. The present results demonstrated that 2-deoxyglucose uptake by the cerebral cortex was facilitated by somatostatin and carbachol in both young and old rats.

Original languageEnglish
Pages (from-to)269-272
Number of pages4
JournalEuropean Journal of Pharmacology: Molecular Pharmacology
Volume269
Issue number2
DOIs
Publication statusPublished - 1994 Oct 14
Externally publishedYes

Keywords

  • 2-Deoxyglucose
  • Aging
  • Brain slice
  • Carbachol
  • Cerebral cortex
  • Somatostatin

ASJC Scopus subject areas

  • Pharmacology

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