Abstract
Background: Proton pump inhibitor (PPI) therapy, the first-line treatment for gastroesophageal reflux disease (GERD), is not always effective. This study aimed to examine the effect of pretreatment patient characteristics on response to PPI therapy. Methods: Japanese outpatients with symptomatic GERD scheduled to receive endoscopy and PPI therapy were enrolled in this multicenter prospective observational study. The patients’ characteristics, including GERD and dyspeptic symptoms, anxiety, depression, and quality of life, were assessed using questionnaires before and 2 and 4 weeks after the start of PPI therapy. Factors affecting therapeutic response were examined by simple and multiple regression analyses using three patient-reported outcome measures as objective variables. Results: Data from 182 patients were analyzed. In multiple regression analysis using the residual symptom rate as an objective variable, lower GERD symptom score (p
| Original language | English |
|---|---|
| Pages (from-to) | 1173-1183 |
| Number of pages | 11 |
| Journal | Journal of Gastroenterology |
| Volume | 50 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 2015 Dec 1 |
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Keywords
- Anxiety
- Depression
- Dyspeptic symptoms
- Gastroesophageal reflux disease
- Therapeutic response to proton pump inhibitor therapy
ASJC Scopus subject areas
- Gastroenterology
Cite this
Factors affecting response to proton pump inhibitor therapy in patients with gastroesophageal reflux disease : a multicenter prospective observational study. / Matsuhashi, Nobuyuki; Kudo, Mineo; Yoshida, Norimasa; Murakami, Kazunari; Kato, Mototsugu; Sanuki, Tsuyoshi; Oshio, Atsushi; Joh, Takashi; Higuchi, Kazuhide; Haruma, Ken; Nakada, Koji.
In: Journal of Gastroenterology, Vol. 50, No. 12, 01.12.2015, p. 1173-1183.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Factors affecting response to proton pump inhibitor therapy in patients with gastroesophageal reflux disease
T2 - a multicenter prospective observational study
AU - Matsuhashi, Nobuyuki
AU - Kudo, Mineo
AU - Yoshida, Norimasa
AU - Murakami, Kazunari
AU - Kato, Mototsugu
AU - Sanuki, Tsuyoshi
AU - Oshio, Atsushi
AU - Joh, Takashi
AU - Higuchi, Kazuhide
AU - Haruma, Ken
AU - Nakada, Koji
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Background: Proton pump inhibitor (PPI) therapy, the first-line treatment for gastroesophageal reflux disease (GERD), is not always effective. This study aimed to examine the effect of pretreatment patient characteristics on response to PPI therapy. Methods: Japanese outpatients with symptomatic GERD scheduled to receive endoscopy and PPI therapy were enrolled in this multicenter prospective observational study. The patients’ characteristics, including GERD and dyspeptic symptoms, anxiety, depression, and quality of life, were assessed using questionnaires before and 2 and 4 weeks after the start of PPI therapy. Factors affecting therapeutic response were examined by simple and multiple regression analyses using three patient-reported outcome measures as objective variables. Results: Data from 182 patients were analyzed. In multiple regression analysis using the residual symptom rate as an objective variable, lower GERD symptom score (p
AB - Background: Proton pump inhibitor (PPI) therapy, the first-line treatment for gastroesophageal reflux disease (GERD), is not always effective. This study aimed to examine the effect of pretreatment patient characteristics on response to PPI therapy. Methods: Japanese outpatients with symptomatic GERD scheduled to receive endoscopy and PPI therapy were enrolled in this multicenter prospective observational study. The patients’ characteristics, including GERD and dyspeptic symptoms, anxiety, depression, and quality of life, were assessed using questionnaires before and 2 and 4 weeks after the start of PPI therapy. Factors affecting therapeutic response were examined by simple and multiple regression analyses using three patient-reported outcome measures as objective variables. Results: Data from 182 patients were analyzed. In multiple regression analysis using the residual symptom rate as an objective variable, lower GERD symptom score (p
KW - Anxiety
KW - Depression
KW - Dyspeptic symptoms
KW - Gastroesophageal reflux disease
KW - Therapeutic response to proton pump inhibitor therapy
UR - http://www.scopus.com/inward/record.url?scp=84949532753&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84949532753&partnerID=8YFLogxK
U2 - 10.1007/s00535-015-1073-0
DO - 10.1007/s00535-015-1073-0
M3 - Article
VL - 50
SP - 1173
EP - 1183
JO - Journal of Gastroenterology
JF - Journal of Gastroenterology
SN - 0944-1174
IS - 12
ER -