Factors affecting response to proton pump inhibitor therapy in patients with gastroesophageal reflux disease

a multicenter prospective observational study

Nobuyuki Matsuhashi, Mineo Kudo, Norimasa Yoshida, Kazunari Murakami, Mototsugu Kato, Tsuyoshi Sanuki, Atsushi Oshio, Takashi Joh, Kazuhide Higuchi, Ken Haruma, Koji Nakada

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Proton pump inhibitor (PPI) therapy, the first-line treatment for gastroesophageal reflux disease (GERD), is not always effective. This study aimed to examine the effect of pretreatment patient characteristics on response to PPI therapy. Methods: Japanese outpatients with symptomatic GERD scheduled to receive endoscopy and PPI therapy were enrolled in this multicenter prospective observational study. The patients’ characteristics, including GERD and dyspeptic symptoms, anxiety, depression, and quality of life, were assessed using questionnaires before and 2 and 4 weeks after the start of PPI therapy. Factors affecting therapeutic response were examined by simple and multiple regression analyses using three patient-reported outcome measures as objective variables. Results: Data from 182 patients were analyzed. In multiple regression analysis using the residual symptom rate as an objective variable, lower GERD symptom score (p 

Original languageEnglish
Pages (from-to)1173-1183
Number of pages11
JournalJournal of Gastroenterology
Volume50
Issue number12
DOIs
Publication statusPublished - 2015 Dec 1

Fingerprint

Proton Pump Inhibitors
Gastroesophageal Reflux
Observational Studies
Prospective Studies
Therapeutics
Regression Analysis
Endoscopy
Outpatients
Anxiety
Quality of Life
Depression

Keywords

  • Anxiety
  • Depression
  • Dyspeptic symptoms
  • Gastroesophageal reflux disease
  • Therapeutic response to proton pump inhibitor therapy

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Factors affecting response to proton pump inhibitor therapy in patients with gastroesophageal reflux disease : a multicenter prospective observational study. / Matsuhashi, Nobuyuki; Kudo, Mineo; Yoshida, Norimasa; Murakami, Kazunari; Kato, Mototsugu; Sanuki, Tsuyoshi; Oshio, Atsushi; Joh, Takashi; Higuchi, Kazuhide; Haruma, Ken; Nakada, Koji.

In: Journal of Gastroenterology, Vol. 50, No. 12, 01.12.2015, p. 1173-1183.

Research output: Contribution to journalArticle

Matsuhashi, Nobuyuki ; Kudo, Mineo ; Yoshida, Norimasa ; Murakami, Kazunari ; Kato, Mototsugu ; Sanuki, Tsuyoshi ; Oshio, Atsushi ; Joh, Takashi ; Higuchi, Kazuhide ; Haruma, Ken ; Nakada, Koji. / Factors affecting response to proton pump inhibitor therapy in patients with gastroesophageal reflux disease : a multicenter prospective observational study. In: Journal of Gastroenterology. 2015 ; Vol. 50, No. 12. pp. 1173-1183.
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