Failure of ovulation after neonatal administration of 5α-dihydrotestosterone to female rats

S. Mizukami, K. Yamanouchi, Y. Arai, R. Yanai, H. Nagasawa

    Research output: Chapter in Book/Report/Conference proceedingChapter

    4 Citations (Scopus)

    Abstract

    Wistar female rats were injected with testosterone (T) or 5α-dihydrotestosterone (5α-DHT) from the day of birth (=day 1) to day 5. Neonatal treatment with 1 mg of T resulted in anovulatory persistent estrous syndrome in 100% of the animals. In the females treated with 1 mg of 5α-DHT, 88.2% of the treated rats were sterile at 120 days of age. Treatment with 0.5 mg 5α-DHT was also effective in inducing anovulatory sterility, the incidence of sterility being 71.4%. In the females injected with 0.1 mg 5α-DHT, 42.9% of the animals were anovulatory at 120 days of age. These results suggest that non-aromatizable androgen, 5α-DHT, can permanently suppress the development of the female type of neuroendocrine regulation.

    Original languageEnglish
    Title of host publicationEndokrinologie
    Pages1-6
    Number of pages6
    Volume79
    Edition1
    Publication statusPublished - 1982

    Fingerprint

    Dihydrotestosterone
    Ovulation
    Infertility
    Androgens
    Testosterone
    Wistar Rats
    Parturition
    Incidence
    Therapeutics

    ASJC Scopus subject areas

    • Endocrinology

    Cite this

    Mizukami, S., Yamanouchi, K., Arai, Y., Yanai, R., & Nagasawa, H. (1982). Failure of ovulation after neonatal administration of 5α-dihydrotestosterone to female rats. In Endokrinologie (1 ed., Vol. 79, pp. 1-6)

    Failure of ovulation after neonatal administration of 5α-dihydrotestosterone to female rats. / Mizukami, S.; Yamanouchi, K.; Arai, Y.; Yanai, R.; Nagasawa, H.

    Endokrinologie. Vol. 79 1. ed. 1982. p. 1-6.

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Mizukami, S, Yamanouchi, K, Arai, Y, Yanai, R & Nagasawa, H 1982, Failure of ovulation after neonatal administration of 5α-dihydrotestosterone to female rats. in Endokrinologie. 1 edn, vol. 79, pp. 1-6.
    Mizukami S, Yamanouchi K, Arai Y, Yanai R, Nagasawa H. Failure of ovulation after neonatal administration of 5α-dihydrotestosterone to female rats. In Endokrinologie. 1 ed. Vol. 79. 1982. p. 1-6
    Mizukami, S. ; Yamanouchi, K. ; Arai, Y. ; Yanai, R. ; Nagasawa, H. / Failure of ovulation after neonatal administration of 5α-dihydrotestosterone to female rats. Endokrinologie. Vol. 79 1. ed. 1982. pp. 1-6
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    AU - Yanai, R.

    AU - Nagasawa, H.

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