Ferromagnetic Ultrasound Microbubbles Contrast Agent

Kawan Soetanto, Hiroshi Watarai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

Microbubbles have attracted attention as ultrasonic contrast agents because their ultrasonic scattering property is excellent in comparison with other ultrasonic contrast agents. In the development of ultrasound contrast agent, the main difficulties accounted are the making of small microbubbles less than 10 μm and the elongation of the lifetime of microbubbles. A new ultrasonic contrast agent, which is microbubbles typed coating by surfactant, has been developed. The contrast images produced by different-sized microbubbles contrast agents are studied quantitatively. Furthermore, a ferromagnetic ultrasound contrast agent was also studied for its potential as a Drug Delivery System (DDS). In this paper, a new ultrasonic contrast agent for the Drug Delivery System will be discussed. Ferromagnetic materials are placed on the surfaces of the surfactant microbubbles developed in our laboratory for the above purpose. Multivalent ions such as calcium ions are used to put the ferromagnetic materials on the surfaces of the microbubbles. It is confirmed that the developed magnetic microbubbles could be lead by a permanent magnet. The performance of the magnetic microbubbles is evaluated by measuring the time dependence of the attenuation constant as one of their acoustic properties.

Original languageEnglish
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
EditorsR.S. Leder
Pages1226-1229
Number of pages4
Volume2
Publication statusPublished - 2003
EventA New Beginning for Human Health: Proceddings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Cancun, Mexico
Duration: 2003 Sep 172003 Sep 21

Other

OtherA New Beginning for Human Health: Proceddings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CountryMexico
CityCancun
Period03/9/1703/9/21

Fingerprint

Contrast Media
Ultrasonics
Ferromagnetic materials
Surface-Active Agents
Ultrasonic scattering
Surface active agents
Ions
Acoustic properties
Permanent magnets
Elongation
Calcium
Coatings

Keywords

  • Acoustic contrast agent
  • DDS
  • Magnetic carbon
  • Magnetic microbubbles
  • Magnetite

ASJC Scopus subject areas

  • Bioengineering

Cite this

Soetanto, K., & Watarai, H. (2003). Ferromagnetic Ultrasound Microbubbles Contrast Agent. In R. S. Leder (Ed.), Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Vol. 2, pp. 1226-1229)

Ferromagnetic Ultrasound Microbubbles Contrast Agent. / Soetanto, Kawan; Watarai, Hiroshi.

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. ed. / R.S. Leder. Vol. 2 2003. p. 1226-1229.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Soetanto, K & Watarai, H 2003, Ferromagnetic Ultrasound Microbubbles Contrast Agent. in RS Leder (ed.), Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. vol. 2, pp. 1226-1229, A New Beginning for Human Health: Proceddings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Cancun, Mexico, 03/9/17.
Soetanto K, Watarai H. Ferromagnetic Ultrasound Microbubbles Contrast Agent. In Leder RS, editor, Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 2. 2003. p. 1226-1229
Soetanto, Kawan ; Watarai, Hiroshi. / Ferromagnetic Ultrasound Microbubbles Contrast Agent. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. editor / R.S. Leder. Vol. 2 2003. pp. 1226-1229
@inproceedings{403d02b9819447b8aa4e8f17e74859d8,
title = "Ferromagnetic Ultrasound Microbubbles Contrast Agent",
abstract = "Microbubbles have attracted attention as ultrasonic contrast agents because their ultrasonic scattering property is excellent in comparison with other ultrasonic contrast agents. In the development of ultrasound contrast agent, the main difficulties accounted are the making of small microbubbles less than 10 μm and the elongation of the lifetime of microbubbles. A new ultrasonic contrast agent, which is microbubbles typed coating by surfactant, has been developed. The contrast images produced by different-sized microbubbles contrast agents are studied quantitatively. Furthermore, a ferromagnetic ultrasound contrast agent was also studied for its potential as a Drug Delivery System (DDS). In this paper, a new ultrasonic contrast agent for the Drug Delivery System will be discussed. Ferromagnetic materials are placed on the surfaces of the surfactant microbubbles developed in our laboratory for the above purpose. Multivalent ions such as calcium ions are used to put the ferromagnetic materials on the surfaces of the microbubbles. It is confirmed that the developed magnetic microbubbles could be lead by a permanent magnet. The performance of the magnetic microbubbles is evaluated by measuring the time dependence of the attenuation constant as one of their acoustic properties.",
keywords = "Acoustic contrast agent, DDS, Magnetic carbon, Magnetic microbubbles, Magnetite",
author = "Kawan Soetanto and Hiroshi Watarai",
year = "2003",
language = "English",
volume = "2",
pages = "1226--1229",
editor = "R.S. Leder",
booktitle = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",

}

TY - GEN

T1 - Ferromagnetic Ultrasound Microbubbles Contrast Agent

AU - Soetanto, Kawan

AU - Watarai, Hiroshi

PY - 2003

Y1 - 2003

N2 - Microbubbles have attracted attention as ultrasonic contrast agents because their ultrasonic scattering property is excellent in comparison with other ultrasonic contrast agents. In the development of ultrasound contrast agent, the main difficulties accounted are the making of small microbubbles less than 10 μm and the elongation of the lifetime of microbubbles. A new ultrasonic contrast agent, which is microbubbles typed coating by surfactant, has been developed. The contrast images produced by different-sized microbubbles contrast agents are studied quantitatively. Furthermore, a ferromagnetic ultrasound contrast agent was also studied for its potential as a Drug Delivery System (DDS). In this paper, a new ultrasonic contrast agent for the Drug Delivery System will be discussed. Ferromagnetic materials are placed on the surfaces of the surfactant microbubbles developed in our laboratory for the above purpose. Multivalent ions such as calcium ions are used to put the ferromagnetic materials on the surfaces of the microbubbles. It is confirmed that the developed magnetic microbubbles could be lead by a permanent magnet. The performance of the magnetic microbubbles is evaluated by measuring the time dependence of the attenuation constant as one of their acoustic properties.

AB - Microbubbles have attracted attention as ultrasonic contrast agents because their ultrasonic scattering property is excellent in comparison with other ultrasonic contrast agents. In the development of ultrasound contrast agent, the main difficulties accounted are the making of small microbubbles less than 10 μm and the elongation of the lifetime of microbubbles. A new ultrasonic contrast agent, which is microbubbles typed coating by surfactant, has been developed. The contrast images produced by different-sized microbubbles contrast agents are studied quantitatively. Furthermore, a ferromagnetic ultrasound contrast agent was also studied for its potential as a Drug Delivery System (DDS). In this paper, a new ultrasonic contrast agent for the Drug Delivery System will be discussed. Ferromagnetic materials are placed on the surfaces of the surfactant microbubbles developed in our laboratory for the above purpose. Multivalent ions such as calcium ions are used to put the ferromagnetic materials on the surfaces of the microbubbles. It is confirmed that the developed magnetic microbubbles could be lead by a permanent magnet. The performance of the magnetic microbubbles is evaluated by measuring the time dependence of the attenuation constant as one of their acoustic properties.

KW - Acoustic contrast agent

KW - DDS

KW - Magnetic carbon

KW - Magnetic microbubbles

KW - Magnetite

UR - http://www.scopus.com/inward/record.url?scp=1542361549&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1542361549&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:1542361549

VL - 2

SP - 1226

EP - 1229

BT - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

A2 - Leder, R.S.

ER -