FGF-2/calcium phosphate composite layer to resist bacterial infection

Y. Sogo, A. Ito, H. Mutsuzaki, A. Oyane, M. Onoguchi, N. Ichinose, M. Sakane, N. Ochiai

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

A FGF-2-apatite composite layer (FGF-AP layer) was formed on the surface of Ti screws in a supersaturated calcium phosphate solution supplemented with FGF-2. By an in vitro study using fibroblastic NIH3T3 cells, it was confirmed that FGF-2 was immobilized in the layer without complete denaturation although the composite layer was formed at 37°C. When Ti screws with the FGF-AP layer were percutaneously implanted in the proximal tibial metaphysis of 16 rabbits, no osteomyelitis was observed in any rabbits although a FGF-2-free AP layer allowed osteomyelitis in some cases in our previous study. These results suggest that a FGF-AP layer formed on Ti screws is useful for resisting bacterial infection during external fixations.

Original languageEnglish
Pages (from-to)691-694
Number of pages4
JournalKey Engineering Materials
Volume330-332 I
DOIs
Publication statusPublished - 2007

Keywords

  • Adhesion
  • Bacterial infection
  • Coprecipitation
  • External fixation
  • FGF-2

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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