First demonstration of multi-color 3-D in vivo imaging using ultra-compact Compton camera

Aya Kishimoto, Jun Kataoka, Takanori Taya, Leo Tagawa, Saku Mochizuki, Shinji Ohsuka, Yuto Nagao, Keisuke Kurita, Mitsutaka Yamaguchi, Naoki Kawachi, Keiko Matsunaga, Hayato Ikeda, Eku Shimosegawa, Jun Hatazawa

    Research output: Contribution to journalArticle

    13 Citations (Scopus)

    Abstract

    In the field of nuclear medicine, single photon emission tomography and positron emission tomography are the two most common techniques in molecular imaging, but the available radioactive tracers have been limited either by energy range or difficulties in production and delivery. Thus, the use of a Compton camera, which features gamma-ray imaging of arbitrary energies from a few hundred keV to more than MeV, is eagerly awaited along with potential new tracers which have never been used in current modalities. In this paper, we developed an ultra-compact Compton camera that weighs only 580 g. The camera consists of fine-pixelized Ce-doped Gd3Al2Ga3O12 scintillators coupled with multi-pixel photon counter arrays. We first investigated the 3-D imaging capability of our camera system for a diffuse source of a planar geometry, and then conducted small animal imaging as pre-clinical evaluation. For the first time, we successfully carried out the 3-D color imaging of a live mouse in just 2 h. By using tri-color gamma-ray fusion images, we confirmed that 131I, 85Sr, and 65Zn can be new tracers that concentrate in each target organ.

    Original languageEnglish
    Article number2110
    JournalScientific Reports
    Volume7
    Issue number1
    DOIs
    Publication statusPublished - 2017 Dec 1

    Fingerprint

    cameras
    tracers
    color
    tomography
    gamma rays
    nuclear medicine
    photons
    organs
    scintillation counters
    mice
    animals
    positrons
    delivery
    counters
    fusion
    pixels
    energy
    evaluation
    geometry

    ASJC Scopus subject areas

    • General

    Cite this

    First demonstration of multi-color 3-D in vivo imaging using ultra-compact Compton camera. / Kishimoto, Aya; Kataoka, Jun; Taya, Takanori; Tagawa, Leo; Mochizuki, Saku; Ohsuka, Shinji; Nagao, Yuto; Kurita, Keisuke; Yamaguchi, Mitsutaka; Kawachi, Naoki; Matsunaga, Keiko; Ikeda, Hayato; Shimosegawa, Eku; Hatazawa, Jun.

    In: Scientific Reports, Vol. 7, No. 1, 2110, 01.12.2017.

    Research output: Contribution to journalArticle

    Kishimoto, A, Kataoka, J, Taya, T, Tagawa, L, Mochizuki, S, Ohsuka, S, Nagao, Y, Kurita, K, Yamaguchi, M, Kawachi, N, Matsunaga, K, Ikeda, H, Shimosegawa, E & Hatazawa, J 2017, 'First demonstration of multi-color 3-D in vivo imaging using ultra-compact Compton camera', Scientific Reports, vol. 7, no. 1, 2110. https://doi.org/10.1038/s41598-017-02377-w
    Kishimoto, Aya ; Kataoka, Jun ; Taya, Takanori ; Tagawa, Leo ; Mochizuki, Saku ; Ohsuka, Shinji ; Nagao, Yuto ; Kurita, Keisuke ; Yamaguchi, Mitsutaka ; Kawachi, Naoki ; Matsunaga, Keiko ; Ikeda, Hayato ; Shimosegawa, Eku ; Hatazawa, Jun. / First demonstration of multi-color 3-D in vivo imaging using ultra-compact Compton camera. In: Scientific Reports. 2017 ; Vol. 7, No. 1.
    @article{5162cb44207344a49ecfe9d8c13eb116,
    title = "First demonstration of multi-color 3-D in vivo imaging using ultra-compact Compton camera",
    abstract = "In the field of nuclear medicine, single photon emission tomography and positron emission tomography are the two most common techniques in molecular imaging, but the available radioactive tracers have been limited either by energy range or difficulties in production and delivery. Thus, the use of a Compton camera, which features gamma-ray imaging of arbitrary energies from a few hundred keV to more than MeV, is eagerly awaited along with potential new tracers which have never been used in current modalities. In this paper, we developed an ultra-compact Compton camera that weighs only 580 g. The camera consists of fine-pixelized Ce-doped Gd3Al2Ga3O12 scintillators coupled with multi-pixel photon counter arrays. We first investigated the 3-D imaging capability of our camera system for a diffuse source of a planar geometry, and then conducted small animal imaging as pre-clinical evaluation. For the first time, we successfully carried out the 3-D color imaging of a live mouse in just 2 h. By using tri-color gamma-ray fusion images, we confirmed that 131I, 85Sr, and 65Zn can be new tracers that concentrate in each target organ.",
    author = "Aya Kishimoto and Jun Kataoka and Takanori Taya and Leo Tagawa and Saku Mochizuki and Shinji Ohsuka and Yuto Nagao and Keisuke Kurita and Mitsutaka Yamaguchi and Naoki Kawachi and Keiko Matsunaga and Hayato Ikeda and Eku Shimosegawa and Jun Hatazawa",
    year = "2017",
    month = "12",
    day = "1",
    doi = "10.1038/s41598-017-02377-w",
    language = "English",
    volume = "7",
    journal = "Scientific Reports",
    issn = "2045-2322",
    publisher = "Nature Publishing Group",
    number = "1",

    }

    TY - JOUR

    T1 - First demonstration of multi-color 3-D in vivo imaging using ultra-compact Compton camera

    AU - Kishimoto, Aya

    AU - Kataoka, Jun

    AU - Taya, Takanori

    AU - Tagawa, Leo

    AU - Mochizuki, Saku

    AU - Ohsuka, Shinji

    AU - Nagao, Yuto

    AU - Kurita, Keisuke

    AU - Yamaguchi, Mitsutaka

    AU - Kawachi, Naoki

    AU - Matsunaga, Keiko

    AU - Ikeda, Hayato

    AU - Shimosegawa, Eku

    AU - Hatazawa, Jun

    PY - 2017/12/1

    Y1 - 2017/12/1

    N2 - In the field of nuclear medicine, single photon emission tomography and positron emission tomography are the two most common techniques in molecular imaging, but the available radioactive tracers have been limited either by energy range or difficulties in production and delivery. Thus, the use of a Compton camera, which features gamma-ray imaging of arbitrary energies from a few hundred keV to more than MeV, is eagerly awaited along with potential new tracers which have never been used in current modalities. In this paper, we developed an ultra-compact Compton camera that weighs only 580 g. The camera consists of fine-pixelized Ce-doped Gd3Al2Ga3O12 scintillators coupled with multi-pixel photon counter arrays. We first investigated the 3-D imaging capability of our camera system for a diffuse source of a planar geometry, and then conducted small animal imaging as pre-clinical evaluation. For the first time, we successfully carried out the 3-D color imaging of a live mouse in just 2 h. By using tri-color gamma-ray fusion images, we confirmed that 131I, 85Sr, and 65Zn can be new tracers that concentrate in each target organ.

    AB - In the field of nuclear medicine, single photon emission tomography and positron emission tomography are the two most common techniques in molecular imaging, but the available radioactive tracers have been limited either by energy range or difficulties in production and delivery. Thus, the use of a Compton camera, which features gamma-ray imaging of arbitrary energies from a few hundred keV to more than MeV, is eagerly awaited along with potential new tracers which have never been used in current modalities. In this paper, we developed an ultra-compact Compton camera that weighs only 580 g. The camera consists of fine-pixelized Ce-doped Gd3Al2Ga3O12 scintillators coupled with multi-pixel photon counter arrays. We first investigated the 3-D imaging capability of our camera system for a diffuse source of a planar geometry, and then conducted small animal imaging as pre-clinical evaluation. For the first time, we successfully carried out the 3-D color imaging of a live mouse in just 2 h. By using tri-color gamma-ray fusion images, we confirmed that 131I, 85Sr, and 65Zn can be new tracers that concentrate in each target organ.

    UR - http://www.scopus.com/inward/record.url?scp=85019946602&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=85019946602&partnerID=8YFLogxK

    U2 - 10.1038/s41598-017-02377-w

    DO - 10.1038/s41598-017-02377-w

    M3 - Article

    C2 - 28522868

    AN - SCOPUS:85019946602

    VL - 7

    JO - Scientific Reports

    JF - Scientific Reports

    SN - 2045-2322

    IS - 1

    M1 - 2110

    ER -