First demonstration of multi-color 3-D in vivo imaging using ultra-compact Compton camera

Aya Kishimoto, Jun Kataoka, Takanori Taya, Leo Tagawa, Saku Mochizuki, Shinji Ohsuka, Yuto Nagao, Keisuke Kurita, Mitsutaka Yamaguchi, Naoki Kawachi, Keiko Matsunaga, Hayato Ikeda, Eku Shimosegawa, Jun Hatazawa

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    21 Citations (Scopus)

    Abstract

    In the field of nuclear medicine, single photon emission tomography and positron emission tomography are the two most common techniques in molecular imaging, but the available radioactive tracers have been limited either by energy range or difficulties in production and delivery. Thus, the use of a Compton camera, which features gamma-ray imaging of arbitrary energies from a few hundred keV to more than MeV, is eagerly awaited along with potential new tracers which have never been used in current modalities. In this paper, we developed an ultra-compact Compton camera that weighs only 580 g. The camera consists of fine-pixelized Ce-doped Gd3Al2Ga3O12 scintillators coupled with multi-pixel photon counter arrays. We first investigated the 3-D imaging capability of our camera system for a diffuse source of a planar geometry, and then conducted small animal imaging as pre-clinical evaluation. For the first time, we successfully carried out the 3-D color imaging of a live mouse in just 2 h. By using tri-color gamma-ray fusion images, we confirmed that 131I, 85Sr, and 65Zn can be new tracers that concentrate in each target organ.

    Original languageEnglish
    Article number2110
    JournalScientific reports
    Volume7
    Issue number1
    DOIs
    Publication statusPublished - 2017 Dec 1

    ASJC Scopus subject areas

    • General

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  • Cite this

    Kishimoto, A., Kataoka, J., Taya, T., Tagawa, L., Mochizuki, S., Ohsuka, S., Nagao, Y., Kurita, K., Yamaguchi, M., Kawachi, N., Matsunaga, K., Ikeda, H., Shimosegawa, E., & Hatazawa, J. (2017). First demonstration of multi-color 3-D in vivo imaging using ultra-compact Compton camera. Scientific reports, 7(1), [2110]. https://doi.org/10.1038/s41598-017-02377-w