First Trial of the Chronic Animal Examination of the Artificial Myocardial Function

Yasuyuki Shiraishi, T. Yambe, Y. Saijo, K. Matsue, M. Shibata, H. Liu, T. Sugai, A. Tanaka, S. Konno, H. Song, A. Baba, K. Imachi, M. Yoshizawa, S. Nitta, H. Sasada, K. Tabayashi, R. Sakata, Y. Sato, M. Umezu, D. Homma

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Thromboembolic and haemorrhagic complications are the primary causes of mortality and morbidity in patients with artificial hearts, which are known to be induced by the interactions between blood flow and artificial material surfaces. The authors have been developing a new mechanical artificial myocardial assist device by using a sophisticated shape memory alloy fibre in order to achieve the mechanical cardiac support from outside of the heart without a direct blood contacting surface. The original material employed as the actuator of artificial myocardial assist devices was 100um fibred-shaped, which was composed of covalent and metallic bonding structure and designed to generate 4-7% shortening by Joule heating induced by the electric current input. Prior to the experiment, the myocardial streamlines were investigated by using a MDCT, and the design of artificial myocardial assist devices were refined based on the concept of Torrent-Guasp's myocardial band theory. As the hydrodynamic or hemodynamic examination exhibited the remarkable increase of cardiac systolic work by the assistance of the artificial myocardial contraction in the originally designed mock circulatory system as well as in the acute animal experiments, the chronic animal test has been started in a goat. Total weight of the device including the actuator was around 150g, and the electric power was supplied percutaneously. The device could be successfully installed into thoracic cavity, which was able to be girdling the left ventricle. In the chronic animal trial, the complication in respect to the diastolic dysfunction by the artificial myocardial compression was not observed.

Original languageEnglish
Title of host publication13th International Conference on Biomedical Engineering - ICBME 2008
Pages2268-2271
Number of pages4
DOIs
Publication statusPublished - 2009 Dec 1
Event13th International Conference on Biomedical Engineering, ICBME 2008 - , Singapore
Duration: 2008 Dec 32008 Dec 6

Publication series

NameIFMBE Proceedings
Volume23
ISSN (Print)1680-0737

Conference

Conference13th International Conference on Biomedical Engineering, ICBME 2008
CountrySingapore
Period08/12/308/12/6

Keywords

  • Artificial myocardium
  • chronic animal experiment
  • hemodynamics
  • myocardial band
  • shape memory alloy fibre

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

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    Shiraishi, Y., Yambe, T., Saijo, Y., Matsue, K., Shibata, M., Liu, H., Sugai, T., Tanaka, A., Konno, S., Song, H., Baba, A., Imachi, K., Yoshizawa, M., Nitta, S., Sasada, H., Tabayashi, K., Sakata, R., Sato, Y., Umezu, M., & Homma, D. (2009). First Trial of the Chronic Animal Examination of the Artificial Myocardial Function. In 13th International Conference on Biomedical Engineering - ICBME 2008 (pp. 2268-2271). (IFMBE Proceedings; Vol. 23). https://doi.org/10.1007/978-3-540-92841-6_569