Flunitrazepam effects on human sleep EEG spectra: Differences in NREM, REM and individual responses

Sunao Uchida, Nobuyuki Okudaira, Kyoko Nishihara, Yoshinobu Iguchi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Flunitrazepam (FNZ) (4 mg), an intermediate type benzodiazepine (BDZ) hypnotic was administered orally to five healthy male subjects (Ss) for seven consecutive nights. Sleep EEG from the baseline night (BLN), the initial drug night (IDN), the fourth and the seventh drug nights (4DN, 7DN) was subjected to fast Fourier transform (FFT) analysis. During NREM sleep of 4DN and 7DN sigma band (11.0-12.5 Hz) activity was similarly enhanced in every S. In REM of 4DN and 7DN the beta band (23.0-3-9.0 Hz) was enhanced, but with larger variations among Ss. High intra-individual consistency of the relative EEG power patterns on 4DN and 7DN was observed. These results suggest that 1) EEG responses to FNZ are different in sleep states; explorations of these differences may provide better understandings of sleep mechanisms, and 2) individual variations in EEG responses may reflect individual variations of the BDZ receptor system. These methods may be useful for exploring receptor changes in neuropsychiatric disorders.

Original languageEnglish
JournalLife Sciences
Volume58
Issue number10
DOIs
Publication statusPublished - 1996 Feb 2
Externally publishedYes

Fingerprint

Flunitrazepam
Electroencephalography
Sleep
Fourier Analysis
GABA-A Receptors
Hypnotics and Sedatives
Benzodiazepines
Pharmaceutical Preparations
Fast Fourier transforms
Healthy Volunteers

Keywords

  • Benzodiazepine
  • FFT analysis
  • Neurophysiology
  • Sleep EEG

ASJC Scopus subject areas

  • Pharmacology

Cite this

Flunitrazepam effects on human sleep EEG spectra : Differences in NREM, REM and individual responses. / Uchida, Sunao; Okudaira, Nobuyuki; Nishihara, Kyoko; Iguchi, Yoshinobu.

In: Life Sciences, Vol. 58, No. 10, 02.02.1996.

Research output: Contribution to journalArticle

Uchida, Sunao ; Okudaira, Nobuyuki ; Nishihara, Kyoko ; Iguchi, Yoshinobu. / Flunitrazepam effects on human sleep EEG spectra : Differences in NREM, REM and individual responses. In: Life Sciences. 1996 ; Vol. 58, No. 10.
@article{d39f330cd5bf4740a6d79c18a809fa12,
title = "Flunitrazepam effects on human sleep EEG spectra: Differences in NREM, REM and individual responses",
abstract = "Flunitrazepam (FNZ) (4 mg), an intermediate type benzodiazepine (BDZ) hypnotic was administered orally to five healthy male subjects (Ss) for seven consecutive nights. Sleep EEG from the baseline night (BLN), the initial drug night (IDN), the fourth and the seventh drug nights (4DN, 7DN) was subjected to fast Fourier transform (FFT) analysis. During NREM sleep of 4DN and 7DN sigma band (11.0-12.5 Hz) activity was similarly enhanced in every S. In REM of 4DN and 7DN the beta band (23.0-3-9.0 Hz) was enhanced, but with larger variations among Ss. High intra-individual consistency of the relative EEG power patterns on 4DN and 7DN was observed. These results suggest that 1) EEG responses to FNZ are different in sleep states; explorations of these differences may provide better understandings of sleep mechanisms, and 2) individual variations in EEG responses may reflect individual variations of the BDZ receptor system. These methods may be useful for exploring receptor changes in neuropsychiatric disorders.",
keywords = "Benzodiazepine, FFT analysis, Neurophysiology, Sleep EEG",
author = "Sunao Uchida and Nobuyuki Okudaira and Kyoko Nishihara and Yoshinobu Iguchi",
year = "1996",
month = "2",
day = "2",
doi = "10.1016/0024-3205(96)00026-4",
language = "English",
volume = "58",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",
number = "10",

}

TY - JOUR

T1 - Flunitrazepam effects on human sleep EEG spectra

T2 - Differences in NREM, REM and individual responses

AU - Uchida, Sunao

AU - Okudaira, Nobuyuki

AU - Nishihara, Kyoko

AU - Iguchi, Yoshinobu

PY - 1996/2/2

Y1 - 1996/2/2

N2 - Flunitrazepam (FNZ) (4 mg), an intermediate type benzodiazepine (BDZ) hypnotic was administered orally to five healthy male subjects (Ss) for seven consecutive nights. Sleep EEG from the baseline night (BLN), the initial drug night (IDN), the fourth and the seventh drug nights (4DN, 7DN) was subjected to fast Fourier transform (FFT) analysis. During NREM sleep of 4DN and 7DN sigma band (11.0-12.5 Hz) activity was similarly enhanced in every S. In REM of 4DN and 7DN the beta band (23.0-3-9.0 Hz) was enhanced, but with larger variations among Ss. High intra-individual consistency of the relative EEG power patterns on 4DN and 7DN was observed. These results suggest that 1) EEG responses to FNZ are different in sleep states; explorations of these differences may provide better understandings of sleep mechanisms, and 2) individual variations in EEG responses may reflect individual variations of the BDZ receptor system. These methods may be useful for exploring receptor changes in neuropsychiatric disorders.

AB - Flunitrazepam (FNZ) (4 mg), an intermediate type benzodiazepine (BDZ) hypnotic was administered orally to five healthy male subjects (Ss) for seven consecutive nights. Sleep EEG from the baseline night (BLN), the initial drug night (IDN), the fourth and the seventh drug nights (4DN, 7DN) was subjected to fast Fourier transform (FFT) analysis. During NREM sleep of 4DN and 7DN sigma band (11.0-12.5 Hz) activity was similarly enhanced in every S. In REM of 4DN and 7DN the beta band (23.0-3-9.0 Hz) was enhanced, but with larger variations among Ss. High intra-individual consistency of the relative EEG power patterns on 4DN and 7DN was observed. These results suggest that 1) EEG responses to FNZ are different in sleep states; explorations of these differences may provide better understandings of sleep mechanisms, and 2) individual variations in EEG responses may reflect individual variations of the BDZ receptor system. These methods may be useful for exploring receptor changes in neuropsychiatric disorders.

KW - Benzodiazepine

KW - FFT analysis

KW - Neurophysiology

KW - Sleep EEG

UR - http://www.scopus.com/inward/record.url?scp=0343396486&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0343396486&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(96)00026-4

DO - 10.1016/0024-3205(96)00026-4

M3 - Article

C2 - 8602113

AN - SCOPUS:0343396486

VL - 58

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

IS - 10

ER -