Flunitrazepam effects on human sleep EEG spectra II: Sigma and beta alterations during NREM sleep

Sunao Uchida, Nobuyuki Okudaira, Kyoko Nishihara, Yoshinobu Iguchi, Xin Tan

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Flunitrazepam (FNZ) is known to enhance the higher EEG frequencies, including sigma (10-15 Hz) and beta (20-28 Hz). Both sigma and beta frequency bands show an inverse relationship with delta (0.3-3 Hz) during NREM periods, as we have previously reported. It is not known whether generation of these two EEG frequencies is mediated by the same or different neuronal mechanisms. In this report, we compare alterations of delta, sigma and beta EEG induced by FNZ (4 mg) orally administered to five healthy male subjects for seven consecutive nights. Sleep EEG on the baseline night (BLN), and the fourth and seventh drug nights (4DN, 7DN) was subjected to fast Fourier transform (FFT) analysis. On drug nights, sigma was enhanced without regard to delta amount, but beta was enhanced only during epochs containing low delta. Thus, sigma and beta EEG were altered differently by the same pharmacological agent. These results suggest that sigma and beta EEG are mediated by different neuronal mechanisms.

Original languageEnglish
JournalLife Sciences
Volume59
Issue number9
Publication statusPublished - 1996 Jul 26
Externally publishedYes

Fingerprint

Flunitrazepam
Electroencephalography
Sleep
Fourier Analysis
Pharmaceutical Preparations
Fast Fourier transforms
Frequency bands
Healthy Volunteers
Pharmacology

Keywords

  • benzodiazepine
  • computer analysis
  • delta
  • neurophysiology
  • sigma beta
  • sleep EEG

ASJC Scopus subject areas

  • Pharmacology

Cite this

Uchida, S., Okudaira, N., Nishihara, K., Iguchi, Y., & Tan, X. (1996). Flunitrazepam effects on human sleep EEG spectra II: Sigma and beta alterations during NREM sleep. Life Sciences, 59(9).

Flunitrazepam effects on human sleep EEG spectra II : Sigma and beta alterations during NREM sleep. / Uchida, Sunao; Okudaira, Nobuyuki; Nishihara, Kyoko; Iguchi, Yoshinobu; Tan, Xin.

In: Life Sciences, Vol. 59, No. 9, 26.07.1996.

Research output: Contribution to journalArticle

Uchida, S, Okudaira, N, Nishihara, K, Iguchi, Y & Tan, X 1996, 'Flunitrazepam effects on human sleep EEG spectra II: Sigma and beta alterations during NREM sleep', Life Sciences, vol. 59, no. 9.
Uchida S, Okudaira N, Nishihara K, Iguchi Y, Tan X. Flunitrazepam effects on human sleep EEG spectra II: Sigma and beta alterations during NREM sleep. Life Sciences. 1996 Jul 26;59(9).
Uchida, Sunao ; Okudaira, Nobuyuki ; Nishihara, Kyoko ; Iguchi, Yoshinobu ; Tan, Xin. / Flunitrazepam effects on human sleep EEG spectra II : Sigma and beta alterations during NREM sleep. In: Life Sciences. 1996 ; Vol. 59, No. 9.
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