Abstract
Flunitrazepam (FNZ) is known to enhance the higher EEG frequencies, including sigma (10-15 Hz) and beta (20-28 Hz). Both sigma and beta frequency bands show an inverse relationship with delta (0.3-3 Hz) during NREM periods, as we have previously reported. It is not known whether generation of these two EEG frequencies is mediated by the same or different neuronal mechanisms. In this report, we compare alterations of delta, sigma and beta EEG induced by FNZ (4 mg) orally administered to five healthy male subjects for seven consecutive nights. Sleep EEG on the baseline night (BLN), and the fourth and seventh drug nights (4DN, 7DN) was subjected to fast Fourier transform (FFT) analysis. On drug nights, sigma was enhanced without regard to delta amount, but beta was enhanced only during epochs containing low delta. Thus, sigma and beta EEG were altered differently by the same pharmacological agent. These results suggest that sigma and beta EEG are mediated by different neuronal mechanisms.
| Original language | English |
|---|---|
| Journal | Life Sciences |
| Volume | 59 |
| Issue number | 9 |
| Publication status | Published - 1996 Jul 26 |
| Externally published | Yes |
Fingerprint
Keywords
- benzodiazepine
- computer analysis
- delta
- neurophysiology
- sigma beta
- sleep EEG
ASJC Scopus subject areas
- Pharmacology
Cite this
Flunitrazepam effects on human sleep EEG spectra II : Sigma and beta alterations during NREM sleep. / Uchida, Sunao; Okudaira, Nobuyuki; Nishihara, Kyoko; Iguchi, Yoshinobu; Tan, Xin.
In: Life Sciences, Vol. 59, No. 9, 26.07.1996.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Flunitrazepam effects on human sleep EEG spectra II
T2 - Sigma and beta alterations during NREM sleep
AU - Uchida, Sunao
AU - Okudaira, Nobuyuki
AU - Nishihara, Kyoko
AU - Iguchi, Yoshinobu
AU - Tan, Xin
PY - 1996/7/26
Y1 - 1996/7/26
N2 - Flunitrazepam (FNZ) is known to enhance the higher EEG frequencies, including sigma (10-15 Hz) and beta (20-28 Hz). Both sigma and beta frequency bands show an inverse relationship with delta (0.3-3 Hz) during NREM periods, as we have previously reported. It is not known whether generation of these two EEG frequencies is mediated by the same or different neuronal mechanisms. In this report, we compare alterations of delta, sigma and beta EEG induced by FNZ (4 mg) orally administered to five healthy male subjects for seven consecutive nights. Sleep EEG on the baseline night (BLN), and the fourth and seventh drug nights (4DN, 7DN) was subjected to fast Fourier transform (FFT) analysis. On drug nights, sigma was enhanced without regard to delta amount, but beta was enhanced only during epochs containing low delta. Thus, sigma and beta EEG were altered differently by the same pharmacological agent. These results suggest that sigma and beta EEG are mediated by different neuronal mechanisms.
AB - Flunitrazepam (FNZ) is known to enhance the higher EEG frequencies, including sigma (10-15 Hz) and beta (20-28 Hz). Both sigma and beta frequency bands show an inverse relationship with delta (0.3-3 Hz) during NREM periods, as we have previously reported. It is not known whether generation of these two EEG frequencies is mediated by the same or different neuronal mechanisms. In this report, we compare alterations of delta, sigma and beta EEG induced by FNZ (4 mg) orally administered to five healthy male subjects for seven consecutive nights. Sleep EEG on the baseline night (BLN), and the fourth and seventh drug nights (4DN, 7DN) was subjected to fast Fourier transform (FFT) analysis. On drug nights, sigma was enhanced without regard to delta amount, but beta was enhanced only during epochs containing low delta. Thus, sigma and beta EEG were altered differently by the same pharmacological agent. These results suggest that sigma and beta EEG are mediated by different neuronal mechanisms.
KW - benzodiazepine
KW - computer analysis
KW - delta
KW - neurophysiology
KW - sigma beta
KW - sleep EEG
UR - http://www.scopus.com/inward/record.url?scp=0030602799&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030602799&partnerID=8YFLogxK
M3 - Article
C2 - 8761034
AN - SCOPUS:0030602799
VL - 59
JO - Life Sciences
JF - Life Sciences
SN - 0024-3205
IS - 9
ER -