Abstract
Fluorescence through proximity: Reduction-triggered fluorescent probes bearing either a fluorescein derivative or triphenylphosphine bind sequence-specifically at the branch site of lariat RNA. The chemical reaction between the two substrates leads to the formation of unquenched fluorescein and the emission of a fluorescence signal (see picture). Prelariat and lariat structures can be distinguished by using this method.
Original language | English |
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Pages (from-to) | 12020-12023 |
Number of pages | 4 |
Journal | Angewandte Chemie - International Edition |
Volume | 50 |
Issue number | 50 |
DOIs | |
Publication status | Published - 2011 Dec 9 |
Keywords
- RNA structures
- biosensors
- fluorescent probes
- lariat RNA
- oligonucleotides
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)