Focused ultrasound thermal treatment using cavitation-enhanced ultrasonic heating

Shin Yoshizawa; Ryo Takagi; Hiroshi Sasaki; Kota Goto; Nobutaka Abe; Shohei Kodera; Hiroshi Ishii; Takashi Suzuki; Yoshihiro Muragaki; Hiroshi Iseki; Shin Ichiro Umemura

doi:10.11239/jsmbe.52.SY-3

Focused ultrasound thermal treatment using cavitation-enhanced ultrasonic heating

Shin Yoshizawa, Ryo Takagi, Hiroshi Sasaki, Kota Goto, Nobutaka Abe, Shohei Kodera, Hiroshi Ishii, Takashi Suzuki, Yoshihiro Muragaki, Hiroshi Iseki, Shin Ichiro Umemura

Research output: Contribution to journal › Article › peer-review

Abstract

High-intensity focused ultrasound (HIFU) causes selective tissue necrosis through heating and is used for a noninvasive treatment of cancer therapy. However, HIFU thermal treatment has a problem of long treatment time because cooling time is needed between two consecutive shots of focused ultrasound exposure to avoid near-field heating owing to heat accumulation. It is known that acoustic cavitation generated in the focal region of HIFU enhances tissue heating. The objective of this study is to develop a method to accelerate HIFU thermal treatment by using cavitation bubbles. Cavitation bubbles were generated at six positions in the direction perpendicular to ultrasound propagation and they were observed by high-speed ultrasound imaging in real time. The coagulation volumes of chicken breast with and without cavitation bubbles were compared. The results show the high efficiency of the proposed HIFU exposure sequence using cavitation-enhanced heating for HIFU thermal treatment.

Original language	English
Pages (from-to)	SY-3-SY-4
Journal	Transactions of Japanese Society for Medical and Biological Engineering
Volume	52
DOIs	https://doi.org/10.11239/jsmbe.52.SY-3
Publication status	Published - 2014 Aug 17
Externally published	Yes

Keywords

Cavitation
HIFU
Microbubbles

ASJC Scopus subject areas

Biomedical Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.11239/jsmbe.52.SY-3

Cite this

@article{e39aa46c653e45a79de8fe02b6c3232f,

title = "Focused ultrasound thermal treatment using cavitation-enhanced ultrasonic heating",

abstract = "High-intensity focused ultrasound (HIFU) causes selective tissue necrosis through heating and is used for a noninvasive treatment of cancer therapy. However, HIFU thermal treatment has a problem of long treatment time because cooling time is needed between two consecutive shots of focused ultrasound exposure to avoid near-field heating owing to heat accumulation. It is known that acoustic cavitation generated in the focal region of HIFU enhances tissue heating. The objective of this study is to develop a method to accelerate HIFU thermal treatment by using cavitation bubbles. Cavitation bubbles were generated at six positions in the direction perpendicular to ultrasound propagation and they were observed by high-speed ultrasound imaging in real time. The coagulation volumes of chicken breast with and without cavitation bubbles were compared. The results show the high efficiency of the proposed HIFU exposure sequence using cavitation-enhanced heating for HIFU thermal treatment.",

keywords = "Cavitation, HIFU, Microbubbles",

author = "Shin Yoshizawa and Ryo Takagi and Hiroshi Sasaki and Kota Goto and Nobutaka Abe and Shohei Kodera and Hiroshi Ishii and Takashi Suzuki and Yoshihiro Muragaki and Hiroshi Iseki and Umemura, {Shin Ichiro}",

year = "2014",

month = aug,

day = "17",

doi = "10.11239/jsmbe.52.SY-3",

language = "English",

volume = "52",

pages = "SY--3--SY--4",

journal = "BME = Bio medical engineering / henshu, Nihon ME Gakkai",

issn = "1347-443X",

publisher = "Nihon M E Gakkai",

}

TY - JOUR

T1 - Focused ultrasound thermal treatment using cavitation-enhanced ultrasonic heating

AU - Yoshizawa, Shin

AU - Takagi, Ryo

AU - Sasaki, Hiroshi

AU - Goto, Kota

AU - Abe, Nobutaka

AU - Kodera, Shohei

AU - Ishii, Hiroshi

AU - Suzuki, Takashi

AU - Muragaki, Yoshihiro

AU - Iseki, Hiroshi

AU - Umemura, Shin Ichiro

PY - 2014/8/17

Y1 - 2014/8/17

N2 - High-intensity focused ultrasound (HIFU) causes selective tissue necrosis through heating and is used for a noninvasive treatment of cancer therapy. However, HIFU thermal treatment has a problem of long treatment time because cooling time is needed between two consecutive shots of focused ultrasound exposure to avoid near-field heating owing to heat accumulation. It is known that acoustic cavitation generated in the focal region of HIFU enhances tissue heating. The objective of this study is to develop a method to accelerate HIFU thermal treatment by using cavitation bubbles. Cavitation bubbles were generated at six positions in the direction perpendicular to ultrasound propagation and they were observed by high-speed ultrasound imaging in real time. The coagulation volumes of chicken breast with and without cavitation bubbles were compared. The results show the high efficiency of the proposed HIFU exposure sequence using cavitation-enhanced heating for HIFU thermal treatment.

AB - High-intensity focused ultrasound (HIFU) causes selective tissue necrosis through heating and is used for a noninvasive treatment of cancer therapy. However, HIFU thermal treatment has a problem of long treatment time because cooling time is needed between two consecutive shots of focused ultrasound exposure to avoid near-field heating owing to heat accumulation. It is known that acoustic cavitation generated in the focal region of HIFU enhances tissue heating. The objective of this study is to develop a method to accelerate HIFU thermal treatment by using cavitation bubbles. Cavitation bubbles were generated at six positions in the direction perpendicular to ultrasound propagation and they were observed by high-speed ultrasound imaging in real time. The coagulation volumes of chicken breast with and without cavitation bubbles were compared. The results show the high efficiency of the proposed HIFU exposure sequence using cavitation-enhanced heating for HIFU thermal treatment.

KW - Cavitation

KW - HIFU

KW - Microbubbles

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U2 - 10.11239/jsmbe.52.SY-3

DO - 10.11239/jsmbe.52.SY-3

M3 - Article

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SN - 1347-443X

VL - 52

SP - SY-3-SY-4

JO - BME = Bio medical engineering / henshu, Nihon ME Gakkai

JF - BME = Bio medical engineering / henshu, Nihon ME Gakkai

ER -

Focused ultrasound thermal treatment using cavitation-enhanced ultrasonic heating

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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