Folate intakes and folate biomarker profiles of pregnant Japanese women in the first trimester

N. Mito, H. Takimoto, K. Umegaki, A. Ishiwaki, K. Kusama, H. Fukuoka, S. Ohta, S. Abe, M. Yamawaki, H. Ishida, N. Yoshiike

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Objective: To assess the status of dietary folate intake, serum and red blood cell (RBC) folate, and related nutritional biomarkers in healthy Japanese women in early pregnancy. Design: A cross-sectional, observational study. Subjects: Pregnant women in the first trimester, at 7-15 weeks gestation (n = 70), who were not consuming any folate supplements or folate fortified foods. Methods: Three-day dietary records were obtained from each subject to assess dietary folate intake. Blood samples were collected for measurement of biomarkers. Biomarkers and nutrient intake were analyzed in two groups defined by their serum folate concentrations: the low folate group (serum folate <9 ng/ml) and the high folate group (serum folate ≥9 ng/ml). Result: Mean serum and RBC folate concentrations inall subjects were 10.3 and 519 ng/ml, respectively. These levels were remarkably higher than the reported values from many other countries despite our subjects receiving no folic acids supplements. However, mean folate intake by our subjects from natural foods was 289μ g/day, which is thought to below according to the Japanese dietary recommendation specified for pregnant women. The intake of spinach and fruits was significantly greater in the high folate group than in the low folate group. Conclusion: Folate intake was thought to be adequate to maintain a desirable level of serum folate concentration in Japanese pregnant women in the first trimester, although the intake of folate from natural food was not high enough to meet the recommended daily intake.

Original languageEnglish
Pages (from-to)83-90
Number of pages8
JournalEuropean Journal of Clinical Nutrition
Volume61
Issue number1
DOIs
Publication statusPublished - 2007 Jan
Externally publishedYes

Fingerprint

First Pregnancy Trimester
Folic Acid
folic acid
Pregnant Women
biomarkers
Biomarkers
blood serum
pregnant women
Serum
natural foods
Food
erythrocytes
Erythrocytes
pregnancy
Fortified Food
Diet Records
fortified foods
Recommended Dietary Allowances
Pregnancy
Spinacia oleracea

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Mito, N., Takimoto, H., Umegaki, K., Ishiwaki, A., Kusama, K., Fukuoka, H., ... Yoshiike, N. (2007). Folate intakes and folate biomarker profiles of pregnant Japanese women in the first trimester. European Journal of Clinical Nutrition, 61(1), 83-90. https://doi.org/10.1038/sj.ejcn.1602497

Folate intakes and folate biomarker profiles of pregnant Japanese women in the first trimester. / Mito, N.; Takimoto, H.; Umegaki, K.; Ishiwaki, A.; Kusama, K.; Fukuoka, H.; Ohta, S.; Abe, S.; Yamawaki, M.; Ishida, H.; Yoshiike, N.

In: European Journal of Clinical Nutrition, Vol. 61, No. 1, 01.2007, p. 83-90.

Research output: Contribution to journalArticle

Mito, N, Takimoto, H, Umegaki, K, Ishiwaki, A, Kusama, K, Fukuoka, H, Ohta, S, Abe, S, Yamawaki, M, Ishida, H & Yoshiike, N 2007, 'Folate intakes and folate biomarker profiles of pregnant Japanese women in the first trimester', European Journal of Clinical Nutrition, vol. 61, no. 1, pp. 83-90. https://doi.org/10.1038/sj.ejcn.1602497
Mito, N. ; Takimoto, H. ; Umegaki, K. ; Ishiwaki, A. ; Kusama, K. ; Fukuoka, H. ; Ohta, S. ; Abe, S. ; Yamawaki, M. ; Ishida, H. ; Yoshiike, N. / Folate intakes and folate biomarker profiles of pregnant Japanese women in the first trimester. In: European Journal of Clinical Nutrition. 2007 ; Vol. 61, No. 1. pp. 83-90.
@article{b097abac05f64d68b701c2882ce35133,
title = "Folate intakes and folate biomarker profiles of pregnant Japanese women in the first trimester",
abstract = "Objective: To assess the status of dietary folate intake, serum and red blood cell (RBC) folate, and related nutritional biomarkers in healthy Japanese women in early pregnancy. Design: A cross-sectional, observational study. Subjects: Pregnant women in the first trimester, at 7-15 weeks gestation (n = 70), who were not consuming any folate supplements or folate fortified foods. Methods: Three-day dietary records were obtained from each subject to assess dietary folate intake. Blood samples were collected for measurement of biomarkers. Biomarkers and nutrient intake were analyzed in two groups defined by their serum folate concentrations: the low folate group (serum folate <9 ng/ml) and the high folate group (serum folate ≥9 ng/ml). Result: Mean serum and RBC folate concentrations inall subjects were 10.3 and 519 ng/ml, respectively. These levels were remarkably higher than the reported values from many other countries despite our subjects receiving no folic acids supplements. However, mean folate intake by our subjects from natural foods was 289μ g/day, which is thought to below according to the Japanese dietary recommendation specified for pregnant women. The intake of spinach and fruits was significantly greater in the high folate group than in the low folate group. Conclusion: Folate intake was thought to be adequate to maintain a desirable level of serum folate concentration in Japanese pregnant women in the first trimester, although the intake of folate from natural food was not high enough to meet the recommended daily intake.",
author = "N. Mito and H. Takimoto and K. Umegaki and A. Ishiwaki and K. Kusama and H. Fukuoka and S. Ohta and S. Abe and M. Yamawaki and H. Ishida and N. Yoshiike",
year = "2007",
month = "1",
doi = "10.1038/sj.ejcn.1602497",
language = "English",
volume = "61",
pages = "83--90",
journal = "European Journal of Clinical Nutrition",
issn = "0954-3007",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Folate intakes and folate biomarker profiles of pregnant Japanese women in the first trimester

AU - Mito, N.

AU - Takimoto, H.

AU - Umegaki, K.

AU - Ishiwaki, A.

AU - Kusama, K.

AU - Fukuoka, H.

AU - Ohta, S.

AU - Abe, S.

AU - Yamawaki, M.

AU - Ishida, H.

AU - Yoshiike, N.

PY - 2007/1

Y1 - 2007/1

N2 - Objective: To assess the status of dietary folate intake, serum and red blood cell (RBC) folate, and related nutritional biomarkers in healthy Japanese women in early pregnancy. Design: A cross-sectional, observational study. Subjects: Pregnant women in the first trimester, at 7-15 weeks gestation (n = 70), who were not consuming any folate supplements or folate fortified foods. Methods: Three-day dietary records were obtained from each subject to assess dietary folate intake. Blood samples were collected for measurement of biomarkers. Biomarkers and nutrient intake were analyzed in two groups defined by their serum folate concentrations: the low folate group (serum folate <9 ng/ml) and the high folate group (serum folate ≥9 ng/ml). Result: Mean serum and RBC folate concentrations inall subjects were 10.3 and 519 ng/ml, respectively. These levels were remarkably higher than the reported values from many other countries despite our subjects receiving no folic acids supplements. However, mean folate intake by our subjects from natural foods was 289μ g/day, which is thought to below according to the Japanese dietary recommendation specified for pregnant women. The intake of spinach and fruits was significantly greater in the high folate group than in the low folate group. Conclusion: Folate intake was thought to be adequate to maintain a desirable level of serum folate concentration in Japanese pregnant women in the first trimester, although the intake of folate from natural food was not high enough to meet the recommended daily intake.

AB - Objective: To assess the status of dietary folate intake, serum and red blood cell (RBC) folate, and related nutritional biomarkers in healthy Japanese women in early pregnancy. Design: A cross-sectional, observational study. Subjects: Pregnant women in the first trimester, at 7-15 weeks gestation (n = 70), who were not consuming any folate supplements or folate fortified foods. Methods: Three-day dietary records were obtained from each subject to assess dietary folate intake. Blood samples were collected for measurement of biomarkers. Biomarkers and nutrient intake were analyzed in two groups defined by their serum folate concentrations: the low folate group (serum folate <9 ng/ml) and the high folate group (serum folate ≥9 ng/ml). Result: Mean serum and RBC folate concentrations inall subjects were 10.3 and 519 ng/ml, respectively. These levels were remarkably higher than the reported values from many other countries despite our subjects receiving no folic acids supplements. However, mean folate intake by our subjects from natural foods was 289μ g/day, which is thought to below according to the Japanese dietary recommendation specified for pregnant women. The intake of spinach and fruits was significantly greater in the high folate group than in the low folate group. Conclusion: Folate intake was thought to be adequate to maintain a desirable level of serum folate concentration in Japanese pregnant women in the first trimester, although the intake of folate from natural food was not high enough to meet the recommended daily intake.

UR - http://www.scopus.com/inward/record.url?scp=33845526997&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33845526997&partnerID=8YFLogxK

U2 - 10.1038/sj.ejcn.1602497

DO - 10.1038/sj.ejcn.1602497

M3 - Article

C2 - 16885932

AN - SCOPUS:33845526997

VL - 61

SP - 83

EP - 90

JO - European Journal of Clinical Nutrition

JF - European Journal of Clinical Nutrition

SN - 0954-3007

IS - 1

ER -