Folding/unfolding kinetics of lattice proteins by applying a simple statistical mechanical model for protein folding

Hiroshi Wako, Haruo Abe

Research output: Book/ReportBook

Abstract

The folding/unfolding kinetics of a three-dimensional lattice protein was studied using a simple statistical mechanical model for protein folding that was previously developed. The model considers the specificity of an amino acid sequence and the native structure of a given protein. The characteristic relaxation rate on the free energy surface was calculated starting from a completely unfolded structure (or native structure) that is assumed to associate with a folding rate (or an unfolding rate). To elucidate the roles of individual amino acid residues in protein folding/unfolding kinetics, the kinetic properties for all possible single amino acid substitutions of these proteins were calculated and their responses were examined. This book presents and discusses research results in the kinetics of protein folding/unfolding.

Original languageEnglish
PublisherNova Science Publishers, Inc.
Number of pages42
ISBN (Print)9781617619229
Publication statusPublished - 2011

Fingerprint

Protein folding
Protein Folding
Statistical Models
Protein Unfolding
Kinetics
Amino Acids
Proteins
Amino Acid Substitution
Free energy
Amino Acid Sequence
Substitution reactions
Research

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Folding/unfolding kinetics of lattice proteins by applying a simple statistical mechanical model for protein folding. / Wako, Hiroshi; Abe, Haruo.

Nova Science Publishers, Inc., 2011. 42 p.

Research output: Book/ReportBook

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