Food anticipation in Bmal1-/- and AAV-Bmal1 rescued mice: A reply to Fuller et al

Ralph E. Mistlberger, Ruud M. Buijs, Etienne Challet, Carolina Escobar, Glenn J. Landry, Andries Kalsbeek, Paul Pevet, Shigenobu Shibata

Research output: Contribution to journalComment/debate

10 Citations (Scopus)

Abstract

Evidence that circadian food-anticipatory activity and temperature rhythms are absent in Bmal1 knockout mice and rescued by restoration of Bmal1 expression selectively in the dorsomedial hypothalamus was published in 2008 by Fuller et al and critiqued in 2009 by Mistlberger et al. Fuller et al have responded to the critique with new information. Here we update our critique in the light of this new information. We also identify and correct factual and conceptual errors in the Fuller et al response. We conclude that the original results of Fuller et al remain inconclusive and fail to clarify the role of Bmal1 or the dorsomedial hypothalamus in the generation of food-entrainable rhythms in mice.

Original languageEnglish
Article number11
JournalJournal of Circadian Rhythms
Volume7
DOIs
Publication statusPublished - 2009 Aug 10

ASJC Scopus subject areas

  • Physiology
  • Endocrine and Autonomic Systems

Fingerprint Dive into the research topics of 'Food anticipation in Bmal1-/- and AAV-Bmal1 rescued mice: A reply to Fuller et al'. Together they form a unique fingerprint.

  • Cite this

    Mistlberger, R. E., Buijs, R. M., Challet, E., Escobar, C., Landry, G. J., Kalsbeek, A., Pevet, P., & Shibata, S. (2009). Food anticipation in Bmal1-/- and AAV-Bmal1 rescued mice: A reply to Fuller et al. Journal of Circadian Rhythms, 7, [11]. https://doi.org/10.1186/1740-3391-7-11