Forebrain lordosis inhibiting system and serotonin neuron in female rats

Effect of p-chloroamphetamine

K. Yamanouchi, H. Watanabe, R. Okada, Y. Arai

    Research output: Contribution to journalArticle

    9 Citations (Scopus)

    Abstract

    Relationship between forebrain lordosis inhibiting system and serotonergic mechanism was examined in estradiol benzoate (EB) and progesterone (P)-primed ovariectomized rats. In order to remove the forebrain inhibition of lordosis response, anterior roof deafferentation (ARD) which interrupts the dorsal inputs to the POA coming down anterior to the anterior commissure or medial preoptic area lesions (POA-L) were made. All experimental females pretreated with EB and P showed high levels of lordotic activity. Soon after the behavioral tests, the animals were injected with 10 mg/kg p-chloroamphetamine (PCA) intraperitoneally and tested again 30 min later. PCA strongly suppressed female sexual behavior. Regardless of the presence of ARD or POA-L, no PCA injected females showed lordosis. From these results, it can be said that serotonin may not directly act on the forebrain lordosis inhibiting system.

    Original languageEnglish
    Pages (from-to)469-474
    Number of pages6
    JournalEndocrinologia Japonica
    Volume29
    Issue number4
    Publication statusPublished - 1982

    Fingerprint

    p-Chloroamphetamine
    Lordosis
    Prosencephalon
    Serotonin
    Neurons
    Preoptic Area
    Sexual Behavior

    ASJC Scopus subject areas

    • Endocrinology

    Cite this

    Forebrain lordosis inhibiting system and serotonin neuron in female rats : Effect of p-chloroamphetamine. / Yamanouchi, K.; Watanabe, H.; Okada, R.; Arai, Y.

    In: Endocrinologia Japonica, Vol. 29, No. 4, 1982, p. 469-474.

    Research output: Contribution to journalArticle

    Yamanouchi, K, Watanabe, H, Okada, R & Arai, Y 1982, 'Forebrain lordosis inhibiting system and serotonin neuron in female rats: Effect of p-chloroamphetamine', Endocrinologia Japonica, vol. 29, no. 4, pp. 469-474.
    Yamanouchi, K. ; Watanabe, H. ; Okada, R. ; Arai, Y. / Forebrain lordosis inhibiting system and serotonin neuron in female rats : Effect of p-chloroamphetamine. In: Endocrinologia Japonica. 1982 ; Vol. 29, No. 4. pp. 469-474.
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