Abstract
The formal total synthesis of (-)-physostigmine via the chiral malonic acid mono-ester ((R)-2-(2-chlorophenyl)-2-methoxycarbonylpropanoic acid, 99% ee) newly prepared by the pig liver esterase (PLE) mediated asymmetric hydrolysis of the corresponding di-ester is described. The CuI-mediated intramolecular aryl amidation under modified Buchwald's conditions is a key reaction to constructing the oxindoline core in the target.
Original language | English |
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Pages (from-to) | 183-190 |
Number of pages | 8 |
Journal | Heterocycles |
Volume | 76 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2008 Dec 1 |
ASJC Scopus subject areas
- Analytical Chemistry
- Pharmacology
- Organic Chemistry