Fos expression induced by warming the preoptic area in rats

Kyoko Yoshida, Megumi Maruyama, Takayoshi Hosono, Kei Nagashima, Yutaka Fukuda, Ruediger Gerstberger, Kazuyuki Kanosue

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The preoptic area (POA) occupies a crucial position among the structures participating in thermoregulation, but we know little about its efferent projections for controlling various effector responses. In this study, we used an immunohistochemical analysis of Fos expression during local warming of the preoptic area. To avoid the effects of anesthesia or stress, which are known to elicit Fos induction in various brain regions, we used a novel thermode specifically designed for chronic warming of discrete brain structures in freely moving rats. At an ambient temperature of 22°C, local POA warming increased Fos immunoreactivity in the supraoptic nucleus (SON) and the periaqueductal gray matter (PAG). Exposure of animals to an ambient temperature of 5°C induced Fos immunoreactivity in the magnocellular paraventricular nucleus (mPVN) and the dorsomedial region of the hypothalamus (DMH). Concurrent warming of the POA suppressed Fos expression in these areas. These findings suggest that thermal information from the preoptic area sends excitatory signals to the SON and the PAG, and inhibitory signals to the mPVN and the DMH.

Original languageEnglish
Pages (from-to)109-117
Number of pages9
JournalBrain Research
Volume933
Issue number2
DOIs
Publication statusPublished - 2002 Apr 19
Externally publishedYes

Fingerprint

Preoptic Area
Supraoptic Nucleus
Periaqueductal Gray
Paraventricular Hypothalamic Nucleus
Hypothalamus
Temperature
Body Temperature Regulation
Brain
Anesthesia
Hot Temperature

Keywords

  • Dorsomedial nucleus
  • Magnocellular paraventricular nucleus
  • Periaqueductal gray matter
  • Preoptic area
  • Supraoptic nucleus
  • Thermoregulation

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Fos expression induced by warming the preoptic area in rats. / Yoshida, Kyoko; Maruyama, Megumi; Hosono, Takayoshi; Nagashima, Kei; Fukuda, Yutaka; Gerstberger, Ruediger; Kanosue, Kazuyuki.

In: Brain Research, Vol. 933, No. 2, 19.04.2002, p. 109-117.

Research output: Contribution to journalArticle

Yoshida, K, Maruyama, M, Hosono, T, Nagashima, K, Fukuda, Y, Gerstberger, R & Kanosue, K 2002, 'Fos expression induced by warming the preoptic area in rats', Brain Research, vol. 933, no. 2, pp. 109-117. https://doi.org/10.1016/S0006-8993(02)02287-4
Yoshida K, Maruyama M, Hosono T, Nagashima K, Fukuda Y, Gerstberger R et al. Fos expression induced by warming the preoptic area in rats. Brain Research. 2002 Apr 19;933(2):109-117. https://doi.org/10.1016/S0006-8993(02)02287-4
Yoshida, Kyoko ; Maruyama, Megumi ; Hosono, Takayoshi ; Nagashima, Kei ; Fukuda, Yutaka ; Gerstberger, Ruediger ; Kanosue, Kazuyuki. / Fos expression induced by warming the preoptic area in rats. In: Brain Research. 2002 ; Vol. 933, No. 2. pp. 109-117.
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