Four aromatic sulfates with an inhibitory effect against HCV NS3 helicase from the crinoid alloeocomatella polycladia

Idam Hermawan, Atsushi Furuta, Masahiro Higashi, Yoshihisa Fujita, Nobuyoshi Akimitsu, Atsuya Yamashita, Kohji Moriishi, Satoshi Tsuneda, Hidenori Tani, Masamichi Nakakoshi, Masayoshi Tsubuki, Yuji Sekiguchi, Naohiro Noda, Junichi Tanaka

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4 Citations (Scopus)

Abstract

Bioassay-guided separation of a lipophilic extract of the crinoid Alloeocomatella polycladia, inhibiting the activity of HCV NS3 helicase, yielded two groups of molecules: cholesterol sulfate and four new aromatic sulfates 1-4. The structures of the aromatics were elucidated by spectroscopic analysis in addition to theoretical studies. The aromatic sulfates 1-4 showed moderate inhibition against NS3 helicase with IC50 values of 71, 95, 7, and 5 μM, respectively.

Original languageEnglish
Article number117
JournalMarine Drugs
Volume15
Issue number4
DOIs
Publication statusPublished - 2017 Apr

Keywords

  • Aromatic sulfates
  • Crinoid
  • Hepatitis C virus (HCV)
  • NS3 helicase

ASJC Scopus subject areas

  • Drug Discovery

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    Hermawan, I., Furuta, A., Higashi, M., Fujita, Y., Akimitsu, N., Yamashita, A., Moriishi, K., Tsuneda, S., Tani, H., Nakakoshi, M., Tsubuki, M., Sekiguchi, Y., Noda, N., & Tanaka, J. (2017). Four aromatic sulfates with an inhibitory effect against HCV NS3 helicase from the crinoid alloeocomatella polycladia. Marine Drugs, 15(4), [117]. https://doi.org/10.3390/md15040117