FoxA1 as a lineage-specific oncogene in luminal type breast cancer

Noritaka Yamaguchi; Emi Ito; Sakura Azuma; Reiko Honma; Yuka Yanagisawa; Akira Nishikawa; Mika Kawamura; Jun ichi Imai; Kuniaki Tatsuta; Jun ichiro Inoue; Kentaro Semba; Shinya Watanabe

doi:10.1016/j.bbrc.2007.11.064

FoxA1 as a lineage-specific oncogene in luminal type breast cancer

Noritaka Yamaguchi, Emi Ito, Sakura Azuma, Reiko Honma, Yuka Yanagisawa, Akira Nishikawa, Mika Kawamura, Jun ichi Imai, Kuniaki Tatsuta, Jun ichiro Inoue, Kentaro Semba^*, Shinya Watanabe

^*Corresponding author for this work

School of Advanced Science and Engineering

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

The forkhead transcription factor FoxA1 is thought to be involved in mammary tumorigenesis. However, the precise role of FoxA1 in breast cancer development is controversial. We examined expression of FoxA1 in 35 human breast cancer cell lines and compared it with that of ErbB2, a marker of poor prognosis in breast cancer. We found that FoxA1 is expressed at high levels in all ErbB2-positive cell lines and a subset of ErbB2-negative cell lines. Down-regulation of FoxA1 by RNA interference significantly suppressed proliferation of ErbB2-negative and FoxA1-positive breast cancer cell lines. Down-regulation of FoxA1 also enhanced the toxic effect of Herceptin on ErbB2-positive cell lines through induction of apoptosis. Taken together with previous data that FoxA1 is a marker of luminal cells in mammary gland, our present results suggest that FoxA1 plays an important role as a lineage-specific oncogene in proliferation of cancer cells derived from mammary luminal cells.

Original language	English
Pages (from-to)	711-717
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	365
Issue number	4
DOIs	https://doi.org/10.1016/j.bbrc.2007.11.064
Publication status	Published - 2008 Jan 25

Keywords

Breast cancer
ER
ErbB2
FoxA1
RNAi

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bbrc.2007.11.064

Cite this

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title = "FoxA1 as a lineage-specific oncogene in luminal type breast cancer",

abstract = "The forkhead transcription factor FoxA1 is thought to be involved in mammary tumorigenesis. However, the precise role of FoxA1 in breast cancer development is controversial. We examined expression of FoxA1 in 35 human breast cancer cell lines and compared it with that of ErbB2, a marker of poor prognosis in breast cancer. We found that FoxA1 is expressed at high levels in all ErbB2-positive cell lines and a subset of ErbB2-negative cell lines. Down-regulation of FoxA1 by RNA interference significantly suppressed proliferation of ErbB2-negative and FoxA1-positive breast cancer cell lines. Down-regulation of FoxA1 also enhanced the toxic effect of Herceptin on ErbB2-positive cell lines through induction of apoptosis. Taken together with previous data that FoxA1 is a marker of luminal cells in mammary gland, our present results suggest that FoxA1 plays an important role as a lineage-specific oncogene in proliferation of cancer cells derived from mammary luminal cells.",

keywords = "Breast cancer, ER, ErbB2, FoxA1, RNAi",

author = "Noritaka Yamaguchi and Emi Ito and Sakura Azuma and Reiko Honma and Yuka Yanagisawa and Akira Nishikawa and Mika Kawamura and Imai, {Jun ichi} and Kuniaki Tatsuta and Inoue, {Jun ichiro} and Kentaro Semba and Shinya Watanabe",

note = "Funding Information: This work was supported by Grant-in-aid for Scientific Research C (K.S.) and Young Scientists B (N.Y.) and “Establishment of Consolidated Research Institute for Advanced Science and Medical Care” Project, Ministry of Education, Culture, Sports, Science and Technology, Japan; “Encouraging Development Strategic Research Centers Program”, New Energy and Industrial Technology Development Organization (NEDO) (S.W.).",

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T1 - FoxA1 as a lineage-specific oncogene in luminal type breast cancer

AU - Yamaguchi, Noritaka

AU - Ito, Emi

AU - Azuma, Sakura

AU - Honma, Reiko

AU - Yanagisawa, Yuka

AU - Nishikawa, Akira

AU - Kawamura, Mika

AU - Imai, Jun ichi

AU - Tatsuta, Kuniaki

AU - Inoue, Jun ichiro

AU - Semba, Kentaro

AU - Watanabe, Shinya

N1 - Funding Information: This work was supported by Grant-in-aid for Scientific Research C (K.S.) and Young Scientists B (N.Y.) and “Establishment of Consolidated Research Institute for Advanced Science and Medical Care” Project, Ministry of Education, Culture, Sports, Science and Technology, Japan; “Encouraging Development Strategic Research Centers Program”, New Energy and Industrial Technology Development Organization (NEDO) (S.W.).

PY - 2008/1/25

Y1 - 2008/1/25

N2 - The forkhead transcription factor FoxA1 is thought to be involved in mammary tumorigenesis. However, the precise role of FoxA1 in breast cancer development is controversial. We examined expression of FoxA1 in 35 human breast cancer cell lines and compared it with that of ErbB2, a marker of poor prognosis in breast cancer. We found that FoxA1 is expressed at high levels in all ErbB2-positive cell lines and a subset of ErbB2-negative cell lines. Down-regulation of FoxA1 by RNA interference significantly suppressed proliferation of ErbB2-negative and FoxA1-positive breast cancer cell lines. Down-regulation of FoxA1 also enhanced the toxic effect of Herceptin on ErbB2-positive cell lines through induction of apoptosis. Taken together with previous data that FoxA1 is a marker of luminal cells in mammary gland, our present results suggest that FoxA1 plays an important role as a lineage-specific oncogene in proliferation of cancer cells derived from mammary luminal cells.

AB - The forkhead transcription factor FoxA1 is thought to be involved in mammary tumorigenesis. However, the precise role of FoxA1 in breast cancer development is controversial. We examined expression of FoxA1 in 35 human breast cancer cell lines and compared it with that of ErbB2, a marker of poor prognosis in breast cancer. We found that FoxA1 is expressed at high levels in all ErbB2-positive cell lines and a subset of ErbB2-negative cell lines. Down-regulation of FoxA1 by RNA interference significantly suppressed proliferation of ErbB2-negative and FoxA1-positive breast cancer cell lines. Down-regulation of FoxA1 also enhanced the toxic effect of Herceptin on ErbB2-positive cell lines through induction of apoptosis. Taken together with previous data that FoxA1 is a marker of luminal cells in mammary gland, our present results suggest that FoxA1 plays an important role as a lineage-specific oncogene in proliferation of cancer cells derived from mammary luminal cells.

KW - Breast cancer

KW - ER

KW - ErbB2

KW - FoxA1

KW - RNAi

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FoxA1 as a lineage-specific oncogene in luminal type breast cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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