Foxg1 Suppresses Early Cortical Cell Fate

Carina Hanashima, Suzanne C. Li, Lijian Shen, Eseng Lai, Gord Fishell

Research output: Contribution to journalArticle

253 Citations (Scopus)

Abstract

During mammalian cerebral corticogenesis, progenitor cells become progressively restricted in the types of neurons they can produce. The molecular mechanism that determines earlier versus later born neuron fate is unknown. We demonstrate here that the generation of the earliest born neurons, the Cajal-Retzius cells, is suppressed by the telencephalic transcription factor Foxg1. In Foxg1 null mutants, we observed an excess of Cajal-Retzius neuron production in the cortex. By conditionally inactivating Foxg1 in cortical progenitors that normally produce deep-layer cortical neurons, we demonstrate that Foxg1 is constitutively required to suppress Cajal-Retzius cell fate. Hence, the competence to generate the earliest born neurons during later cortical development is actively suppressed but not lost.

Original languageEnglish
Pages (from-to)56-59
Number of pages4
JournalScience
Volume303
Issue number5654
DOIs
Publication statusPublished - 2004 Jan 2
Externally publishedYes

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Neurons
Telencephalon
Mental Competency
Transcription Factors
Stem Cells

ASJC Scopus subject areas

  • Medicine(all)
  • General

Cite this

Hanashima, C., Li, S. C., Shen, L., Lai, E., & Fishell, G. (2004). Foxg1 Suppresses Early Cortical Cell Fate. Science, 303(5654), 56-59. https://doi.org/10.1126/science.1090674

Foxg1 Suppresses Early Cortical Cell Fate. / Hanashima, Carina; Li, Suzanne C.; Shen, Lijian; Lai, Eseng; Fishell, Gord.

In: Science, Vol. 303, No. 5654, 02.01.2004, p. 56-59.

Research output: Contribution to journalArticle

Hanashima, C, Li, SC, Shen, L, Lai, E & Fishell, G 2004, 'Foxg1 Suppresses Early Cortical Cell Fate', Science, vol. 303, no. 5654, pp. 56-59. https://doi.org/10.1126/science.1090674
Hanashima C, Li SC, Shen L, Lai E, Fishell G. Foxg1 Suppresses Early Cortical Cell Fate. Science. 2004 Jan 2;303(5654):56-59. https://doi.org/10.1126/science.1090674
Hanashima, Carina ; Li, Suzanne C. ; Shen, Lijian ; Lai, Eseng ; Fishell, Gord. / Foxg1 Suppresses Early Cortical Cell Fate. In: Science. 2004 ; Vol. 303, No. 5654. pp. 56-59.
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