Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis

Shimpei Kawamoto, Mikako Maruya, LuciaM Kato, Wataru Suda, Koji Atarashi, Yasuko Doi, Yumi Tsutsui, Hongyan Qin, Kenya Honda, Takaharu Okada, Masahira Hattori, Sidonia Fagarasan

Research output: Contribution to journalArticle

180 Citations (Scopus)

Abstract

Foxp3+ Tcells play a critical role for the maintenance of immune tolerance. Here we show that in mice, Foxp3+ Tcells contributed to diversification of gut microbiota, particularly of species belonging to Firmicutes. The control of indigenous bacteria by Foxp3+ Tcells involved regulatory functions both outside and inside germinal centers (GCs), consisting of suppression of inflammation and regulation of immunoglobulin A (IgA) selection in Peyer's patches, respectively. Diversified and selected IgAs contributed to maintenance of diversified and balanced microbiota, which in turn facilitated the expansion of Foxp3+ Tcells, induction of GCs, andIgA responses in the gut through a symbiotic regulatory loop. Thus,the adaptive immune system, through cellular and molecular components that arerequired for immune tolerance and through the diversification as well as selection of antibody repertoire, mediates host-microbial symbiosis by controlling the richness and balance of bacterial communities required for homeostasis.

Original languageEnglish
Pages (from-to)152-165
Number of pages14
JournalImmunity
Volume41
Issue number1
DOIs
Publication statusPublished - 2014 Jul 17
Externally publishedYes

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Immune Tolerance
Germinal Center
Immunoglobulin A
Homeostasis
Maintenance
T-Lymphocytes
Peyer's Patches
Symbiosis
Microbiota
Immune System
Inflammation
Bacteria
Antibodies
Gastrointestinal Microbiome
Firmicutes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

Cite this

Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis. / Kawamoto, Shimpei; Maruya, Mikako; Kato, LuciaM; Suda, Wataru; Atarashi, Koji; Doi, Yasuko; Tsutsui, Yumi; Qin, Hongyan; Honda, Kenya; Okada, Takaharu; Hattori, Masahira; Fagarasan, Sidonia.

In: Immunity, Vol. 41, No. 1, 17.07.2014, p. 152-165.

Research output: Contribution to journalArticle

Kawamoto, S, Maruya, M, Kato, L, Suda, W, Atarashi, K, Doi, Y, Tsutsui, Y, Qin, H, Honda, K, Okada, T, Hattori, M & Fagarasan, S 2014, 'Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis', Immunity, vol. 41, no. 1, pp. 152-165. https://doi.org/10.1016/j.immuni.2014.05.016
Kawamoto, Shimpei ; Maruya, Mikako ; Kato, LuciaM ; Suda, Wataru ; Atarashi, Koji ; Doi, Yasuko ; Tsutsui, Yumi ; Qin, Hongyan ; Honda, Kenya ; Okada, Takaharu ; Hattori, Masahira ; Fagarasan, Sidonia. / Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis. In: Immunity. 2014 ; Vol. 41, No. 1. pp. 152-165.
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